Publications by authors named "F Biggio"
The long-term influence of early-life stress on brain neurophysiology has been extensively investigated using different animal models. Among these, repeated maternal separation (RMS) in rodents is one of the most commonly adopted. In this study, we elucidated the long-lasting effects of exposure to postnatal RMS in C57BL/6J adult mice on voluntary alcohol consumption and nucleus accumbens (NAc) neurophysiology.
View Article and Find Full Text PDFIn the last decades, the consumption of energy drinks has risen dramatically, especially among young people, adolescents and athletes, driven by the constant search for ergogenic effects, such as the increase in physical and cognitive performance. In parallel, mixed consumption of energy drinks and ethanol, under a binge drinking modality, under a binge drinking modality, has similarly grown among adolescents. However, little is known whether the combined consumption of these drinks, during adolescence, may have long-term effects on central function, raising the question of the risks of this habit on brain maturation.
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- Drinking alcohol mixed with energy drinks is becoming more common among teens, which can lead to serious long-term problems.
- Studies suggest that this combined drinking may make teens more likely to abuse alcohol and use drugs.
- Researchers used rats to study how this drinking behavior affects brain functions related to addiction, finding that it changes how certain brain cells react to things, possibly leading to risky behaviors later on.
Article Synopsis
- Loss-of-function mutations in the Kv1.1 gene lead to episodic ataxia type 1 (EA1), causing symptoms like cerebellar dysfunction, ataxic attacks, muscle cramps, and epilepsy.
- Current treatments lack drugs that can counteract functional defects in Kv1.1 channels, making precision medicine for EA1 unfeasible.
- The study found that niflumic acid (NFA), an existing analgesic, enhances Kv1.1 channel activity and mitigates EA1 symptoms, showing promise as a therapeutic agent and a model for drug discovery.
Three cases of the malformation of the cortical development are described: a mixed breed dog and a Border Collie pup with a focal and diffuse cortical dysplasia, respectively, and a kitten with lissencephaly. All cases presented with intractable epilepsy and were euthanized, due to the cluster of epileptic seizures. The gross examination at necropsy revealed the morphologic alteration of the telencephalic region in two cases.
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