Publications by authors named "F Bienaime"
Article Synopsis
- High extracellular fluid volume (ECV) in kidney transplant recipients is linked to increased mortality and decreased kidney function (mGFR).
- A study of 2057 kidney transplant recipients found that factors like gender, age, diabetes, and heart issues were associated with higher ECV.
- Elevated ECV three months post-transplant predicts reduced kidney function at 12 months but does not correlate with loss of the transplant itself.
Kidney tubular cells are submitted to two distinct mechanical forces generated by the urine flow: shear stress and hydrostatic pressure. In addition, the mechanical properties of the surrounding extracellular matrix modulate tubule deformation under constraints. These mechanical factors likely play a role in the pathophysiology of kidney diseases as exemplified by autosomal dominant polycystic kidney disease, in which pressure, flow and matrix stiffness have been proposed to modulate the cystic dilation of tubules with mutations.
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- Acute kidney injury (AKI) is linked to higher in-hospital mortality for patients on veno-arterial ECMO, but the specific effects of KDIGO AKI stages have not been fully studied.
- A retrospective analysis of 179 patients revealed that as age increases, the odds of mortality within 30 days rise by 4%, and any presence of AKI increases mortality odds by 59%.
- Higher KDIGO stages of AKI are associated with increased mortality risk at 30 days, indicating that further research is necessary to confirm these preliminary findings.
Article Synopsis
- More old people are getting kidney transplants, and we’re seeing more cases of a condition called MGUS, but we don't know much about how it affects them in the long run.
- The study looked at 70 kidney transplant patients who had MGUS before their surgery and compared them to 114 patients who developed MGUS afterward.
- Patients with MGUS before transplant didn't have higher chances of rejecting their new kidney or dying, but they were more likely to get certain cancers and infections, so doctors should keep an eye on them.