Publications by authors named "F Biccire"
Article Synopsis
- Researchers compared two methods to assess the risk of cardiac events in patients: the Gensini score (which evaluates coronary atherosclerosis burden) and optical coherence tomography (OCT) for plaque morphology.
- Out of 847 patients studied, 56 (6.6%) experienced serious cardiac issues within one year, with higher risks associated with higher Gensini scores and certain OCT features like thin fibrous caps and large lipid arcs.
- Both the Gensini score and specific OCT characteristics were found to be independent predictors of cardiac events, indicating that patients with greater atherosclerosis and vulnerable plaques are at a higher risk for adverse outcomes.
Importance: Previous studies investigated atherosclerotic changes induced by lipid-lowering therapy in extensive coronary segments irrespective of baseline disease burden (a vessel-level approach).
Objective: To investigate the effects of lipid-lowering therapy on coronary lesions with advanced atherosclerotic plaque features and presumably higher risk for future events.
Design, Setting, And Participants: The PACMAN-AMI randomized clinical trial (enrollment: May 2017 to October 2020; final follow-up: October 2021) randomized patients with acute myocardial infarction to receive alirocumab or placebo in addition to high-intensity statin therapy.
Article Synopsis
- Neoatherosclerosis is a major cause of late stent failure after drug-eluting stent implantation, and the study aimed to compare biodegradable (BP) and durable polymer (DP) drug-eluting stents in patients with STEMI over a 3-year period.
- The CONNECT trial randomly assigned 239 STEMI patients to receive either BP-EES or DP-EES, with the primary goal of assessing neoatherosclerosis using optical coherence tomography (OCT) at the 3-year mark.
- Results showed no significant difference in the occurrence of neoatherosclerosis or other complications between the two stent types, indicating that BP-EES did not perform better than DP-EES in preventing neoatherosclerosis after
Mechanical prosthetic heart valves (MPHVs) are commonly used for valvular heart disease in patients with a long life expectancy. Few longitudinal data on the specific causes of hospitalization in patients with MPHV are available. We investigated the risk of all-cause hospitalization and mortality in patients with MPHV.
View Article and Find Full Text PDFBackground: The incidence of new-onset atrial fibrillation (NOAF) is increasing in the last decades. NOAF is associated with worse long-term prognosis. The CHEST score has been recently proposed to stratify the risk of NOAF.
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