Publications by authors named "F Bessone"
Background: Secondary sclerosing cholangitis (SSC), is one of the phenotypes of DILI first described in the 1980s. Check point inhibitors (CPIs) are currently the most frequent cause of SCC.
Aims: To describe the epidemiology, clinical and biochemical features at presentation, differential diagnoses, pathophysiology, imaging, histological characteristics and management associated with SSC.
Background: With the emergence of multidrug-resistant infections, healthcare professionals must evaluate the effectiveness of empiric antibiotic treatments.
Aims: To assess the antibiotic susceptibility patterns of microorganisms causing spontaneous infections in patients with cirrhosis and to evaluate the suitability of empiric antibiotic treatments based on major clinical guidelines.
Methods: This cross-sectional study utilized two datasets from prospective studies of patients with cirrhosis and culture-positive spontaneous bacterial infections in Argentina and Uruguay.
Article Synopsis
- A comprehensive study analyzed 468 cases of idiosyncratic drug-induced liver injury (DILI) in Latin America over a decade, revealing key demographic details such as a predominance of women (62%) and a mean age of 49 years.
- The analysis found that hepatocellular injury was the most common (62%), with significant occurrences of jaundice (60%) and hospitalization (42%), while 4.1% of cases resulted in fatal outcomes.
- The study highlights a rising incidence of liver injuries linked to herbal and dietary supplements, as well as specific drugs like nimesulide and nitrofurantoin, suggesting the need for public health initiatives to educate on the risks associated with these medications.
Introduction: Data on positive rechallenge in idiosyncratic drug-induced liver injury (DILI) are scarce. We aim to analyse the clinical presentation, outcome and drugs associated with positive rechallenge in two DILI registries.
Methods: Cases from the Spanish and Latin American DILI registries were included.