Publications by authors named "F Bertoldo"
Article Synopsis
- Obstructive sleep apnea (OSA) mainly affects obese patients and can lead to serious organ damage, with less understood consequences for bone health related to fat distribution.
- In a study of 49 patients with mild-to-severe OSA, it was found that 63% had increased visceral adipose tissue (iVAT), which correlated with higher rates of hypertension and diabetes, as well as worse nocturnal oxygen levels.
- Patients with iVAT displayed significantly lower lumbar spine trabecular bone scores compared to those with normal visceral fat, indicating a negative impact of VAT on bone quality, which could also link to vertebral fractures.
Hypophosphatasia (HPP) is a rare disorder of the bone metabolism, characterized by genetically determined low alkaline phosphatase (ALP) activity. Low ALP may also be observed in some common causes of bone fragility, such as in osteoporosis treated with antiresorptive drugs. This study aimed to verify whether differences in bone turnover markers (BTMs) could help differentiate adult patients with HPP from those with osteoporosis undergoing antiresorptive treatment.
View Article and Find Full Text PDFThoracic aortic aneurysms (TAAs) represent a serious health concern, as they are associated with early aortic dissection and rupture. TAA formation is triggered by genetic conditions, in particular Marfan syndrome (MFS) and bicuspid aortic valve (BAV). During the aneurysmatic process, aortic endothelial cells can undergo endothelial-to-mesenchymal transition (End-MT) with consequent phenotypic and functional alterations.
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