Publications by authors named "F Bertoglio"
Article Synopsis
- * Cytomegaloviruses (CMVs) can create sustained immune responses, making them promising candidates as vaccine vectors against COVID-19.
- * In a study using a recombinant murine CMV (MCMV) vaccine, not only was robust and long-lasting protection against COVID-19 observed in mice, but it also effectively neutralized variants like Omicron BA.1 after just one dose.
Article Synopsis
- The emergence of Omicron subvariants challenges the effectiveness of current vaccines and therapeutic antibodies, leading to increased breakthrough infections linked to weak mucosal IgA responses from mRNA vaccines.
- Researchers engineered new forms of IgA antibodies that showed significantly improved neutralizing abilities against various Omicron lineages compared to traditional IgG antibodies.
- Administering these enhanced IgA antibodies nasally could offer a promising strategy for both preventing and treating Omicron infections, addressing issues of immune evasion by newer variants.
As of now, the COVID-19 pandemic has spread to over 770 million confirmed cases and caused approximately 7 million deaths. While several vaccines and monoclonal antibodies (mAb) have been developed and deployed, natural selection against immune recognition of viral antigens by antibodies has fueled the evolution of new emerging variants and limited the immune protection by vaccines and mAb. To optimize the efficiency of mAb, it is imperative to understand how they neutralize the variants of concern (VoCs) and to investigate the mutations responsible for immune escape.
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