Publications by authors named "F Berthold"
Background: Liquid biopsies offer less burdensome sensitive disease monitoring. Bone marrow (BM) metastases, common in various cancers including neuroblastoma, is associated with poor outcomes. In pediatric high-risk neuroblastoma most patients initially respond to treatment, but in the majority the disease recurs with only 40% long-term survivors, stressing the need for more sensitive detection of disseminated disease during therapy.
View Article and Find Full Text PDFNoncompliance with therapy is a big obstacle to successful therapy. We aimed to evaluate the prevalence and risk factors affecting the compliance of pediatric cancer patients with therapy in a tertiary care center far away from the capital in a lower-middle income country (LMIC). A retrospective cohort study of reports of all pediatric cancer patients who were diagnosed and started treatment between 2006 and 2010 at South Egypt Cancer Institute (SECI) was done.
View Article and Find Full Text PDFBackground: Substantial progress has been achieved in managing childhood cancers in many high-income countries (HICs). In contrast, survival rates in lower-middle-income countries (LMICs) are less favorable. Here, we aimed to compare outcomes and associated factors between two large institutions; Egypt (LMIC) and Germany (HIC).
View Article and Find Full Text PDFAsymmetric Adrenals: Sexual Dimorphism of Adrenal Tumors.
J Clin Endocrinol Metab
January 2024
Article Synopsis
- Sexual dimorphism influences the occurrence and survival rates of different adrenal tumors, highlighting the importance of gender in diagnosis and prognosis.
- A study with over 8,000 patients found that certain tumor types like adrenocortical carcinoma are more common in females, while neuroblastomas and aldosterone-producing adenomas are less prevalent in the same group.
- There is notable adrenal asymmetry regarding tumor prevalence and size, with implications for understanding tumor development and the need for tailored diagnostic approaches.
Background: The pretreatment International Neuroblastoma Risk Group Staging System (INRGSS) discriminates localized tumors L1/L2 depending on the absence/presence of image-defined risk factors (IDRFs) at diagnosis. Referring to this new staging system, we assessed initial imaging of localized thoracic neuroblastoma (NB) and ganglioneuroma (GN) and the extent of initial tumor resection.
Methods: Patients with localized thoracic NB/GN from the German clinical trials NB97 and NB2004 were included.