Publications by authors named "F Bergamini"
Neglected tropical viral diseases are a burden to social and economic welfare being responsible for higher pathogen-related mortality rates and chronic debilitating patient conditions. Climatic changes have widened up the infectibility ratio of such diseases, with autochthonous transmission in formerly temperate-to-cold environments. The slow-paced development of potential vaccines followed by the inexistence of antiviral drugs for such diseases considerably worsens the situation.
View Article and Find Full Text PDFAntibacterial profile and antiproliferative activities over human tumor cells of new silver(I) complexes containing two distinct trifluoromethyl uracil isomers.
J Inorg Biochem
January 2025
Article Synopsis
- New silver(I) complexes of 5-(trifluoromethyl)uracil (5TFMU) and 6-(trifluoromethyl)uracil (6TFMU) were synthesized and characterized for their antibacterial and antiproliferative activities.
- Structural analyses indicated that 5TFMU acts as a tridentate ligand forming distinct coordination environments, while 6TFMU forms a more complex polymeric structure with multiple coordination sites.
- Both complexes showed modest antibacterial activity, with Ag-6TFMU displaying better efficacy against certain tumor cells, particularly in prostate and kidney cell lines, while Ag-5TFMU had a broader activity profile against various tumor cells but lacked selectivity.
Purpose: To investigate the myopic macular neovascularization (mMNV) features on dynamic video color OCT angiography (OCTA) and the diagnostic rate versus the static, 4-segmentations visualization mode.
Design: Retrospective cohort study.
Participants: Fifty-four patients with mMNV.
Further line treatment of patients with advanced stage AL amyloidosis with cardiac involvement is challenging. Venetoclax is a promising option, especially in t(11;14) and BCL2 expression.In our multicentre observational study, we report the 3-year follow-up of Venetoclax treatment in 9 patients with advanced, relapsed or refractory AL amyloidosis with t(11;14) and BCL-2 expression in > 50% of plasma cells.
View Article and Find Full Text PDFBackgroundHuman leishmaniasis is a protozoan disease transmitted by sand flies and endemic in the Mediterranean region. In Italy, leishmaniasis is present in the south and the western coastal regions, with an epidemic peak detected in northern Italy in the early 1970s.AimTo examine temporal trends, and demographic, clinical, geographical and environmental features of human leishmaniasis cases recorded by the local health unit (LHU) of Bologna, northern Italy.
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