Publications by authors named "F Benoit"
Background: Mutations in the LRRK2 gene are the most common genetic cause of Parkinson disease but are believed to play no significant role in Lewy body disease (LBD).
Objectives: As the frequency of G2019S LRRK2 mutation is extremely high in North African patients with Parkinson disease, we postulate that the high prevalence of LBD in North Africa might be due to the same mutation because LBD and Parkinson disease share many clinical, pathological, and genetic features.
Methods: We screened patients with LBD or prodromal LBD for the G2019S mutation of LRRK2.
This study investigates the translational and rovibrational energy of vacuum-ultraviolet (VUV) photodesorbed CO molecules from a CO polycrystalline ice (15 K) at ∼8 eV. The electronic excitation was produced by a pulsed VUV laser, and the photodesorption of CO molecules in their ground and first vibrational states was observed using resonance enhanced multiphoton ionization. Time-of-flight and rotationally resolved spectra were measured, and the kinetic and internal energy distribution were obtained.
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- Bovine viral diarrhoea (BVD) is a significant economic threat to livestock due to its complex transmission and diverse pestiviruses (BVDV-1, -2, and HoBi-like pestivirus), prompting eradication plans in several countries, including France since 2019.
- A study collected 1,037 BVDV-positive cattle samples in France from 2011 to 2023, revealing that two main BVDV-1 genotypes (1e and 1b) make up 88% of the sequences, with other less common genotypes also identified.
- Phylogenetic analysis showed different global distribution patterns for the main genotypes, but their relative frequencies have remained stable in France since
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- A study was done to see if a new method to predict brain age can help understand brain health better and measure how lifestyle changes might help keep our brains in good condition.
- They looked at data from 742 people, including those with healthy brains and various types of cognitive issues, using special software to analyze brain scans.
- The results showed that people with mild cognitive impairment and Alzheimer's had older brain ages than their actual ages, and using brain age was better at identifying brain problems than just looking at regular age.
Ion mobility mass spectrometry (IM-MS) measures the mass, size, and shape of ions in the same experiment, and structural information is provided via collision cross-section (CCS) values. The majority of commercially available IM-MS instrumentation relies on the use of CCS calibrants, and here, we present data from a family of poly(l-lysine) dendrimers and explore their suitability for this purpose. In order to test these compounds, we employed three different IM-MS platforms (Agilent 6560 IM-QToF, Waters Synapt G2, and a home-built variable temperature drift tube IM-MS) and used them to investigate six different generations of dendrimers in two buffer gases (helium and nitrogen).
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