LDLR-Mediated Targeting and Productive Uptake of siRNA-Peptide Ligand Conjugates In Vitro and In Vivo.

Small RNA molecules such as microRNA and small interfering RNA (siRNA) have become promising therapeutic agents because of their specificity and their potential to modulate gene expression. Any gene of interest can be potentially up- or down-regulated, making RNA-based technology the healthcare breakthrough of our era. However, the functional and specific delivery of siRNAs into tissues of interest and into the cytosol of target cells remains highly challenging, mainly due to the lack of efficient and selective delivery systems.

Generic stress rectification in nonlinear elastic media.

Stress propagation in nonlinear media is crucial in cell biology, where molecular motors exert anisotropic force dipoles on the fibrous cytoskeleton. While the force dipoles can be either contractile or expansile, a medium made of fibers which buckle under compression rectifies these stresses towards a biologically crucial contraction. A general understanding of this rectification phenomenon as a function of the medium's elasticity is however lacking.

Study of a tool supporting the link between community and hospital care: a six-month study of a geriatric hotline.

The growing elderly population and their overlapping conditions require more specialised care. The difficulties accessing scheduled hospital admissions often lead to visits to accident and emergency departments (A&E), which can have a harmful effect on these patients. The French Regional Health Agency (ARS) has developed geriatric hotlines in certain geriatric departments.

[Study of a tool supporting the community-hospital link, the Central Hospital Group's geriatric hotline, over a period of 6 months].

The increasing elderly population and their overlapping conditions require more specialised care. The difficulties accessing scheduled hospital admission lead to visits to Accident and Emergency Department (A&E), which have a harmful effect on these patients. The Regional Health Agency (ARS) has developed geriatric hotlines in all geriatric sectors.