Publications by authors named "F Benito Bartolome"

Ferromagnetism is the collective alignment of atomic spins that retain a net magnetic moment below the Curie temperature, even in the absence of external magnetic fields. Reducing this fundamental property into strictly two-dimensions was proposed in metal-organic coordination networks, but thus far has eluded experimental realization. In this work, we demonstrate that extended, cooperative ferromagnetism is feasible in an atomically thin two-dimensional metal-organic coordination network, despite only ≈ 5% of the monolayer being composed of Fe atoms.

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Objective: The emergence of Electronic Health Records (EHRs) has been beneficial in processing administrative and clinical data for quality healthcare information. Despite being patient-centered, a number of these technologies have a fractional consideration of the human-computer interaction, which affects the healthcare professionals as end-users. This attempted to surface the healthcare providers' preferences of an ideal EHR system interface in the community setting.

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Loss-of-function (LOF) mutations in gene, which encodes progranulin (PGRN), cause frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). FTLD-TDP is one of the most common forms of early onset dementia, but its pathogenesis is not fully understood. Mitochondrial dysfunction has been associated with several neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS).

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Article Synopsis
  • Parkinson's disease (PD) is a neurodegenerative disorder linked to the loss of dopamine-producing neurons, and current treatments only manage symptoms, highlighting the need for new therapeutic targets.
  • The transcription factor CCAAT/Enhancer Binding Protein β (C/EBPβ) shows altered levels in various neurodegenerative diseases, indicating its potential as a therapeutic target for PD, particularly in regulating genes like mitochondrial transcription factor A (TFAM).
  • Research showed that overexpressing C/EBPβ enhances TFAM activity, while reducing C/EBPβ levels led to increased TFAM and other mitochondrial markers, suggesting a role of C/EBPβ in mitochondrial function and autophagy processes in PD.
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