Publications by authors named "F Ben-Rached"
Article Synopsis
- Theileria parasites lead to the transformation of bovine leukocytes, causing them to proliferate rapidly and evade cell death.
- The study investigates mA RNA modifications in T. annulata-infected leukocytes, using sequencing and bioinformatics to analyze these methylation patterns.
- Findings suggest that mA modifications correlate with leukocyte proliferation rates and may influence cell cycle dynamics, with HIF-1α identified as a potential regulator of these modifications, highlighting the importance of mRNA methylation in the interaction between the parasite and host cells.
Article Synopsis
- Klebsiella pneumoniae is a significant healthcare threat due to the rise of hypervirulent and multidrug-resistant strains, which poses challenges in treatment options.
- A genomic analysis of 328 MDR K. pneumoniae strains from a hospital in Jeddah, Saudi Arabia, revealed the dominance of Clonal Complex 14, particularly the ST2096 strain, which has shown continuous expansion.
- The study highlights the strains' ability to acquire resistance genes and their high virulence, with significant clinical implications that underscore the need for monitoring and understanding these emerging strains to prevent outbreaks.
MicroRNAs (miRNAs) are small noncoding RNAs that can play critical roles in regulating various cellular processes, including during many parasitic infections. Here, we report a regulatory role for miR-34c-3p in cAMP-independent regulation of host cell protein kinase A (PKA) activity in -infected bovine leukocytes. We identified (cAMP-dependent protein kinase A type II-beta regulatory subunit) as a novel miR-34c-3p target gene and demonstrate how infection-induced upregulation of miR-34c-3p repressed PRKAR2B expression to increase PKA activity.
View Article and Find Full Text PDFStudies have shown that variants in bedaquiline-resistance genes can occur in isolates from bedaquiline-naive patients. We assessed the prevalence of variants in all bedaquiline-candidate-resistance genes in bedaquiline-naive patients, investigated the association between these variants and lineage, and the effect on phenotype. We used whole-genome sequencing to identify variants in bedaquiline-resistance genes in isolates from 509 bedaquiline treatment naive South African tuberculosis patients.
View Article and Find Full Text PDFMonitoring SARS-CoV-2 spread and evolution through genome sequencing is essential in handling the COVID-19 pandemic. Here, we sequenced 892 SARS-CoV-2 genomes collected from patients in Saudi Arabia from March to August 2020. We show that two consecutive mutations (R203K/G204R) in the nucleocapsid (N) protein are associated with higher viral loads in COVID-19 patients.
View Article and Find Full Text PDF