Publications by authors named "F Bahrehmand"
Background: Dysregulated levels of cytokines may lead to cytokine storm, which has been implicated in the immunopathogenesis of coronavirus disease 2019 (COVID-19). Here in the current study, the role of microRNA (miR)-155-5p, miR-146a, and miR-221-3p in the regulation of the immune responses and inflammatory state in patients with COVID-19 was investigated.
Methods: In this case-control study, peripheral blood samples were obtained from 75 COVID-19 subjects and 100 healthy controls.
Article Synopsis
- Epilepsy is linked to excessive electrical activity and oxidative stress in neurons, and this study investigates the neuroprotective potential of crocin, a saffron-derived compound, when delivered via solid lipid nanoparticles (SLNC) against PTZ-induced epilepsy in rats.* -
- Rats were treated with SLNC and pure crocin for 28 days, and results showed improved memory and reduced oxidative stress markers (MDA and pro-inflammatory cytokines) with SLNC, indicating its effectiveness compared to pure crocin.* -
- The findings suggest that SLNC enhances antioxidant capacity and neuroprotective factors while lowering inflammatory responses and apoptosis in neurons, highlighting its potential as a promising therapeutic approach for managing seizures.*
Introduction: Cardiovascular disease (CVD) is the most critical extra-articular manifestation of rheumatoid arthritis, and inflammatory molecules contribute to its pathogenesis. Recently, CXCL9 has been considered an inflammatory chemokine associated with the pathogenesis of CVD. Here, we evaluated the association of plasma CXCL9 with well-established cardiac biomarkers, including HS-CRP (High sensitivity C-reactive protein) and NT-ProBNP (N-terminal pro-B-type natriuretic peptide), in newly diagnosed and under-treatment RA patients.
View Article and Find Full Text PDFPreeclampsia is the most common and serious complication of pregnancy. Variants of Sirtuin-1 (SIRT1) as a key player in the regulation of oxidant/antioxidant signaling pathways might be involved in the pathogenesis of preeclampsia. In the present case-control study 300 women with and without preeclampsia were studied for SIRT1 variants (rs7895833, rs7069102, and rs2273773) and haplotypes.
View Article and Find Full Text PDFBackground: Inflammasomes are a group of molecules that are strongly involved in causing inflammation. This study aimed to evaluate the expression of NLR family pyrin domain containing 1 (NLRP1), NLRP3, and Apoptosis-associated speck-like protein containing a CARD (ASC) as well as their association with serum level of interleukin (IL)-1β in patients with coronavirus disease 2019 (COVID-19).
Methods: Thirty COVID-19 patients and 30 healthy subjects (HS) were recruited.