Publications by authors named "F Badia-Boungou"

Article Synopsis
  • Enteroviruses (EVs) affect millions each year, causing a range of illnesses from mild to severe, including dilated cardiomyopathy.
  • The connection between EV infections and type 1 diabetes mellitus (T1DM) is debated, with differing opinions on the strength of the correlation and the need for more research.
  • While some countries like the USA and Finland have extensive studies on this relationship, regions like MENA remain underexplored despite high T1DM prevalence, prompting a need for investigation into EVs' role in the disease in these areas.
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Article Synopsis
  • * Seven plants were identified, and their extracts were tested for antienteroviral activity, revealing only the aqueous extract of Syzygium brazzavillense showed significant inhibitory effects on certain viruses at specific concentrations.
  • * The study concludes that aqueous extracts of Syzygium brazzavillense have potential as a treatment against enterovirus infections, highlighting its efficacy in inhibiting virus replication in vitro.
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Aims: Enteroviruses, especially coxsackieviruses B (CV-B), have been associated with the pathogenesis of type 1 diabetes (T1D). An anti-CV-B4 neutralizing activity in saliva of T1D patients was previously reported. Our aim was to study the association between the saliva anti-CV-B4 neutralizing activity and immune parameters in T1D patients in comparison with non-diabetic individuals.

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Background: Coxsackieviruses B (CV-B) are enteroviruses that have been reported to play a role in the pathogenesis of type 1 diabetes. Enteroviral RNA was detected in the gut mucosa of patients. The mucosal immunity is an interconnected network; therefore, the response to enteroviruses possibly present in the gastrointestinal mucosa can be reflected by specific antibodies in the saliva.

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The role of enteroviruses in type 1 diabetes has long been suspected. A lower risk of type 1 diabetes is associated with breastfeeding, which could be due to a protective effect against enteroviruses. The neutralizing activity of breast milk against CVB4, a representative of enteroviruses was investigated in this study in vitro.

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