Publications by authors named "F BLANK"
Toll-like receptors (TLRs) are central to initiate immune responses against invading pathogens. To ensure host defense while avoiding aberrant activation leading to pathogenic inflammation and autoimmune diseases, TLRs are tightly controlled by multilevel regulatory mechanisms. Through a loss-of-function genetic screen in a reporter cell line engineered to undergo cell death upon TLR7-induced IRF5 activation, we identified here CCDC134 as an essential factor for TLR responses.
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- - The lungs serve as a major interface for interactions with inhaled substances, and they are equipped with various immune cells (like epithelial cells, macrophages, and dendritic cells) to protect against these potential threats.
- - The characteristics of these immune cell populations vary based on their location in the lungs, making them ideal candidates for targeted therapies that can influence immune responses when inhaled.
- - Utilizing nanosized drug carriers for inhalation shows promise for enhancing or regulating immune responses, but careful study is needed to understand their effects and ensure safety for both prevention and treatment of lung-related issues.
Metastasis, the leading cause of cancer death, is closely linked to lactate metabolism. Our study aimed to investigate the role of lactate dehydrogenase B (LDHB), which mainly catalyzes the conversion of lactate to pyruvate, in the metastatic potential of lung cancer. We found that LDHB silencing reduced the invasion and migration ability of lung cancer cells in vitro.
View Article and Find Full Text PDFPurpose: To evaluate the oncological and genitourinary outcomes of various forms of prostate ablation for localized prostate cancer.
Methods: A prospectively managed database included men with localized prostate cancer who underwent prostate ablation during January 2018-August 2023. Patients received either whole or partial-gland ablation using 1 of 3 energy modalities: cryotherapy, High Intensity Focused Ultrasound (HIFU), or Irreversible electroporation (IRE).
Introduction: Positive childbirth expectations are crucial for fostering a positive labor experience and enhancing the health and well-being of both the woman and her newborn. However, the impact of obesity on childbirth expectations remains underexplored. We aim to assess childbirth expectations in women living with obesity to enhance perinatal care tailored to their specific needs.
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