Ultrastructure of psoriatic epidermis.

The ultrastructure of human affected and unaffected psoriatic epidermis was studied in skin biopsies from 5 patients and 3 normal controls. Transmission electron microscopic investigations revealed abnormalities in all cell layers of the affected epidermis. Common to psoriatic keratinocytes from affected epidermis was the reduction of tonofilaments.

Surface ultrastructure of cultures of affected psoriatic keratinocytes, unaffected psoriatic keratinocytes and normal keratinocytes.

The surface structure of 11-12 days old cultures from biopsies of normal skin and uninvolved psoriatic skin was investigated by scanning electron microscopy. The keratinocytes formed flat, thin, and well-organized layers of elongated, tightly apposed cells. Newly-formed cells with few and short microplicae and microvilli were seen at the colony periphery.

A medieval case of metastasizing carcinoma with multiple osteosclerotic bone lesions.

The skeleton of a mature male from the Middle Ages, excavated in Svendborg, Denmark, presented multiple osteosclerotic metastases probably of a carcinoma of the prostate gland. This diagnosis is based on radiographic and histological studies. Coexisting gross changes of the spine are identified as vertebral osteophytosis.

Fetal arterial involvement in Behcet's disease: an electron microscope study.

A fetus, 16 weeks old, was removed by hysterotomy from a patient suffering from Behcet's disease. The patient received systemic steroids during pregnancy. Electron microscopy of the fetal thoracic aorta revealed edema of the sub-endothelial space and of the luminal part of the tunica media, as well as a pronounced rarefaction and disarrangement of the smooth-muscle cells.

Involvement of post-capillary venules in Behçet's disease: an electronmicroscopic study.

In Behçet's disease, severe pathological changes are observed in the post-capillary venules, indicating that the venous side of the circulation is generally involved. It is proposed that one of the initial pathological changes is multiplication of the basal lamina surrounding the post-capillary venule.