Publications by authors named "F B de Lacy"
Background: The optimal treatment of anastomotic leak after rectal cancer resection is unclear. This worldwide cohort study aimed to provide an overview of four treatment strategies applied.
Methods: Patients from 216 centres and 45 countries with anastomotic leak after rectal cancer resection between 2014 and 2018 were included.
Objective: To develop and validate a prediction model (STOMA score) for 1-year stoma-free survival in patients with rectal cancer (RC) with anastomotic leakage (AL).
Background: AL after RC resection often results in a permanent stoma.
Methods: This international retrospective cohort study (TENTACLE-Rectum) encompassed 216 participating centres and included patients who developed AL after RC surgery between 2014 and 2018.
Article Synopsis
- - The study focuses on determining how the time between completing neoadjuvant therapy (NAT) and undergoing total mesorectal excision (TME) affects outcomes in patients with extraperitoneal locally advanced rectal cancer (LARC), hypothesizing that longer intervals might increase pathologic complete response (pCR) rates without raising surgical risks.
- - Researchers analyzed data from 1,506 LARC patients across six centers, categorizing them into groups based on whether the interval between NAT and surgery was short (≤8 weeks), intermediate (>8 and ≤12 weeks), or long (>12 weeks), with a median follow-up of 33 months.
- - Results showed that the overall pCR rate was 17.
Purpose: Comparative studies on efficacy of treatment strategies for anastomotic leakage (AL) after low anterior resection (LAR) are almost non-existent. This study aimed to compare different proactive and conservative treatment approaches for AL after LAR.
Methods: This retrospective cohort study included all patients with AL after LAR in three university hospitals.