Publications by authors named "F B Stapleton"
Background: Contact lens discomfort (CLD) is a common problem for CL wearers, and patients with CLD often have changes in meibomian gland function and structure. In a Phase 2 trial AZR-MD-001 0.5% (AZR) ophthalmic ointment improved meibomian gland dysfunction (MGD) in non-lens wearers.
View Article and Find Full Text PDFThe increased usage of nonrefractive cosmetic contact lenses in Asia and a trend toward increased online purchasing of both refractive and cosmetic contact lenses poses unique challenges in the management of contact lens-related complications. However, regulations have lagged behind this increased uptake in the community. This paper reviews regulations surrounding the manufacturing, import, and distribution of contact lenses in the Asia Pacific region and compares them with international regulations from the European Union and United States.
View Article and Find Full Text PDFArticle Synopsis
- - Meibomian gland dysfunction (MGD) is a major cause of dry eye disease, impacting over a third of the global population, and new treatments like Intense Pulse Light (IPL) and Low-Level Light Therapy (LLLT) have shown promise, though their combined effectiveness hasn't been systematically reviewed.
- - A meta-analysis of 12 studies demonstrated that combining LLLT and IPL therapy significantly improved symptoms in MGD patients, as measured by reductions in the Ocular Surface Disease Index, and increases in Tear Break-up Time and Schirmer test results, with effects observed up to 3 months post-treatment.
- - The study confirms the short-term efficacy of the combined therapies for MGD but notes that while meib
Objective: To identify and assess the quality of currently available validated patient reported outcome measures (PROMs) used to measure the quality of life (QoL) impacts of ocular surface diseases (OSDs).
Methods: A literature search was performed in the PubMed, Embase, Scopus, Cochrane Library, and Web of Science databases. Articles reporting on the development, validation, and use of PROMs specific to ocular surface diseases were included for review.
Article Synopsis
- Genetic information is becoming more integrated into eye care, especially for conditions like retinoblastoma that stem from single gene mutations, while most eye diseases involve multiple genetic variants and environmental influences.
- The article introduces three genetic epidemiology methods for studying complex eye diseases: genome-wide association studies (GWAS), Polygenic Risk Scores (PRS), and Mendelian randomisation (MR).
- GWAS identifies associations between traits and numerous genetic variants, PRS quantifies an individual's genetic risk based on GWAS findings, and MR examines potential causal relationships between traits using genetic variants as proxies.