Extended versus limited mesenteric excision in bowel resection for Crohn's disease: a meta-analysis and systematic review.

Background: There is ongoing debate regarding the benefits of extended mesenteric excision (EME) versus limited mesenteric excision (LME) in intestinal resection for Crohn's disease (CD). Some studies suggest that EME may reduce surgical recurrence, which is defined as the need for reoperation due to disease complications or insufficient response to therapy, when compared with LME. This systematic review and meta-analysis aims to compare postoperative complications, surgical recurrence, and endoscopic recurrence in patients undergoing EME versus LME for CD.

Abdominoperineal Resection in Prone Versus Supine Position: A Systematic Review and Meta-Analysis.

Abdominal perineal resection (APR) remains the gold standard for lower rectal cancer involving the anal sphincter. However, the optimal patient position remains unclear. While lithotomy or Lloyd-Davies are commonly used, APR and extra-levator abdominal perineal excision (ELAPE) in a prone jackknife position have been linked to better oncological outcomes.

Should the Start of Immunosuppressive Treatment for COVID-19 Rely upon the Degree of Inflammation or the Time from Onset?

A COVID-19 model with a viral first-week phase and an inflammatory second phase has been proposed. It has been suggested that immunosuppressive treatment in the first week is harmful. This study aimed to analyze the potential damage of corticosteroids (CS) administered in the first week of COVID-19.

Rifampicin-loaded phthalated cashew gum nano-embedded microparticles intended for pulmonary administration.

Tuberculosis is a serious infectious disease commonly treated with rifampicin (RIF), which has low water solubility and high permeability. Polymeric nanoparticles (PNs) are used for controlled drug delivery to improve drug efficacy. However, PNs can be easily expelled via pulmonary administration.

Prophylactic funnel mesh for preventing parastomal hernia in patients with permanent end stoma: a systematic review and meta-analysis.

Purpose: The high incidence of parastomal hernia (PSH) has led surgeons to study strategies to minimize PSH, including prophylactic mesh placement during permanent stoma creation. There are several studies on prophylactic mesh for preventing PSH with conflicting results and there is limited information on using 3D funnel meshes and their effectiveness in preventing PSH.

Methods: A search was performed on PubMed, Scopus, Cochrane Central Register of Clinical Trials, and Web of Science for studies published up to September 2024.