Publications by authors named "F B Clarke"
Background: Understanding site-related factors that influence enrolment within multicenter randomized controlled trials (RCT) may help reduce trial delays and cost over-runs and prevent early trial discontinuation. In this analysis of PROSPECT (Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial), we describe patient enrolment patterns and examine factors influencing site-based monthly enrolment.
Design: Retrospective analysis of a multicenter RCT.
Chemical imaging of pharmaceutical solid oral dosage forms is a key technique for quality assurance and issue diagnosis. This technique can be further augmented using 3D chemical imaging serial sections and image stacking. However, the additional collection time this entails means that 3D imaging is utilised for a very niche set of applications.
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- Outpatient parenteral antimicrobial therapy (OPAT) can effectively treat fungal infections while reducing the treatment burden and costs, particularly by using the longer dosing intervals of rezafungin.
- A study of 386 patients from 2012 to 2022 found that 11% were treated with echinocandins via OPAT, primarily for Candida infections, achieving a 73% treatment success rate.
- Switching from daily to weekly echinocandin dosing could potentially cut treatment sessions by 52%, although the ongoing need for daily antibiotics limited some of these benefits.
Background: The aim of the study is to assess the possible predictors of microvascular free flap failure and determine the critical postoperative timing of flap failure, thereby minimizing this adverse outcome.
Methods: This is a retrospective single-institutional review of 1569 free flap operations. All free flaps with outcome status recorded were analyzed for possible predictors in the development of microvascular compromise.