Biomarkers.

Background: Chronic pain remains mostly untreated in those with Alzheimer's disease and related dementias (ADRD), mainly due to limited capacity to verbalize pain. Development of reliable objective biomarkers of chronic pain could improve pain assessment and treatment. We explored feasibility and acceptability of using a wearable electroencephalograph (EEG) and a screen-based eye tracker system to identify neural signatures of chronic pain in this population.

Characterization of patients treated at a rare disease referral service: a descriptive study, 2016-2021.

Objective: To analyze the first referral service for rare diseases accredited by the Brazilian Ministry of Health, focusing on referral from the primary healthcare network through to diagnosis.

Methods: This is a descriptive study with patients treated between 2016 and 2021 at a referral hospital service located in Curitiba, Paraná, Brazil. Clinical and epidemiological data were obtained from medical records, as were the results of genetic tests at the hospital's clinical analysis laboratory.

Access to oral health services in the Xukuru do Ororubá Indigenous Territory (2017-2018): analysis of performance indicators.

This ecological study conducted with secondary data extracted from the Indigenous Health Care Information System (SIASI) analyzed the access to oral health services provided to Xukuru do Ororubá Indigenous peoples from 2017 to 2018. The units of analysis were the Indigenous villages. The services delivered by the oral health teams working in the context were analyzed, verifying access and performance indicators and their parameters.

Survival Strategies of : Adaptive Regulation of the Anti-Restriction Gene -H1 Under Stress Conditions.

: The anti-restriction protein ArdA-H1, found in multiresistant (MRSA) strains from the ST239-SCCIII lineage, inhibits restriction-modification systems, fostering horizontal gene transfer (HGT) and supporting genetic adaptability and resistance. This study investigates the regulatory mechanisms controlling H1 expression in under various stress conditions, including acidic pH, iron limitation, and vancomycin exposure, and explores the roles of the Agr quorum sensing system. : The expression of H1 was analyzed in strains exposed to environmental stressors using real-time quantitative reverse transcription PCR.

New insights into the putative role of leucine-rich repeat proteins of and their participation in host cell invasion: an analysis.

Pathogenic are spirochetes that cause leptospirosis, a worldwide zoonotic disease. Leptospirosis affects humans and animals, with approximately 1 million human infections and 60,000 deaths per year. The diversity of leptospiral strains and serovars allied to the fact that pathogenesis is not yet fully understood, make the development of an effective vaccine against leptospirosis a challenge.