Publications by authors named "F Ay"
Summary: With the increased reliance on multi-omics data for bulk and single cell analyses, the availability of robust approaches to perform unsupervised learning for clustering, visualization, and feature selection is imperative. We introduce nipalsMCIA, an implementation of multiple co-inertia analysis (MCIA) for joint dimensionality reduction that solves the objective function using an extension to Non-linear Iterative Partial Least Squares (NIPALS). We applied nipalsMCIA to both bulk and single cell datasets and observed significant speed-up over other implementations for data with a large sample size and/or feature dimension.
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- - The study investigated how nurses' lifelong learning impacts their digital literacy and online information search strategies at a hospital in Istanbul, involving 302 participants.
- - Results showed a positive correlation between higher lifelong learning and improved digital literacy as well as better web-based information search and interpretation skills among nurses.
- - Nurses aged 31 and older exhibited high lifelong learning and digital literacy levels, indicating that their ongoing education enhances their ability to find and interpret information from professional online sources.
Background: Pathologic tissue remodeling with scarring and tissue rigidity has been demonstrated in inflammatory, autoimmune, and allergic diseases. Eosinophilic esophagitis (EoE) is an allergic disease that is diagnosed and managed by repeated biopsy procurement, allowing an understanding of tissue fibroblast dysfunction. While EoE-associated tissue remodeling causes clinical dysphagia, food impactions, esophageal rigidity, and strictures, molecular mechanisms driving these complications remain under investigation.
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- Blocking IL-13 is effective for treating atopic dermatitis (AD), and new research suggests that targeting T cell costimulatory molecules like OX40 and OX40L could also be a beneficial treatment option.
- This study investigates whether targeting CD30L might be an additional therapeutic avenue, by comparing it with existing targets like IL-13 and OX40L using single-cell RNA-seq and a murine model of AD.
- Results showed that blocking CD30L effectively reduced disease symptoms in mice, indicating that targeting the CD30-CD30L pathway could be a promising future treatment for human atopic dermatitis, similar to targeting the OX40-OX40L pathway.