Publications by authors named "F Arredondo"
Alzheimer's disease (AD) is the most common form of dementia, affecting approximately 47 M people worldwide. Histological features and genetic risk factors, among other evidence, supported the amyloid hypothesis of the disease. This neuronocentric paradigm is currently undergoing a shift, considering evidence of the role of other cell types, such as microglia and astrocytes, in disease progression.
View Article and Find Full Text PDFAlzheimer's disease (AD) involves a neurodegenerative process that has not yet been prevented, reversed, or stopped. Continuing with the search for natural pharmacological treatments, flavonoids are a family of compounds with proven neuroprotective effects and multi-targeting behavior. The American genus Dalea L.
View Article and Find Full Text PDFThe role of monoamine oxidase A (MAO-A) in the aggressiveness of prostate cancer (PCa) has been established in recent years. The molecular imaging of MAO-A expression could offer a noninvasive tool for the visualization and quantification of highly aggressive PCa. This study reports the synthesis and preclinical evaluation of C- and F-labeled MAO-A inhibitors as positron emission tomography (PET) tracers for proof-of-concept studies in animal models of PCa.
View Article and Find Full Text PDFArticle Synopsis
- Recent research highlights the role of glial cells, particularly astrocytes, in the progression of neurodegenerative diseases like Alzheimer's, moving beyond the traditional focus solely on neurons.
- Reactive astrogliosis describes the changes that astrocytes undergo in response to tissue damage, which can result in disease-specific astrocyte phenotypes.
- The study of neurotoxic astrocytes in a triple transgenic mouse model of Alzheimer’s disease reveals that their altered functions may lead to harmful outcomes for neurons and could be linked to stress responses and metabolic changes in the brain's environment.
Processing and storing blood samples for future analysis of biomarkers can be challenging in resource limited environments. The preparation of dried blood spots (DBS) from finger-stick collection of whole blood is a widely used and established method as DBS are biosafe, and allow simpler field processing, storage, and transport protocols than serum or plasma. Therefore, DBS are commonly used in population surveys to assess infectious disease and/or micronutrient status.
View Article and Find Full Text PDF