Publications by authors named "F Arienti"
Extracellular vesicles (EVs) derived from the plasma of oncological patients exhibit significant tumor-targeting properties, unlike those from healthy individuals. We have previously shown the feasibility of formulating the near-infrared (NIR) fluorescent dye indocyanine green (ICG) with patient-derived extracellular vesicles (PDEVs) for selective delivery to neoplastic tissue. This staining protocol holds promise for clinical application in intraoperative tumor margin imaging, enabling precise neoplastic tissue resection.
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- Colorectal cancer (CRC) is linked to factors like obesity and inflammation, which may disrupt immune response by accumulating foam cells (FC) in tumors, potentially impacting cancer progression.*
- The study involved analyzing tumor samples from CRC patients to investigate the relationship between FC and immune cell dynamics, highlighting the presence of reduced CD8 T cells and increased regulatory T cells in tumors with high FC accumulation.*
- Results indicated that higher levels of FC are associated with worse outcomes, including lower disease-free survival rates in CRC, and in vitro experiments showed that FC suppress CD8 T cell activity through mechanisms involving TGF-β.*
Objective: To evaluate the association between maternal migration status and preterm birth, and whether a better adherence to antenatal care during pregnancy mitigates the risk of preterm birth.
Design: Population-based cohort.
Setting: Administrative databases of the Lombardy region, Italy.
Family History in Parkinson's Disease: A National Cross-Sectional Study.
Mov Disord Clin Pract
November 2024
Article Synopsis
- Family history of Parkinson's disease (PD) was examined in a study involving 2035 PD patients across 28 Italian centers, revealing that 21.9% had a family history of the disease.
- Familial PD (fPD) patients experienced symptoms at an earlier age compared to sporadic PD (sPD) patients, although both groups showed similar prevalence of motor and nonmotor symptoms.
- The findings suggest that fPD occurs more frequently than previously thought, highlighting the need for comprehensive family history taking to uncover potential disease patterns and risk factors.
Cytomegalovirus (CMV) is the leading infectious cause of brain defects and neurological dysfunctions, including sensorineural hearing loss (SNHL). Targeted screening in neonates failing the hearing screen is currently recommended in Italy according to national guidelines. However, SNHL may not be present at birth; also, congenital CMV (cCMV) may manifest with subtle signs other than SNHL.
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