Publications by authors named "F Ardellier"
A novel methylation class, "neuroepithelial tumor, with PLAGL1 fusion" (NET-PLAGL1), has recently been described, based on epigenetic features, as a supratentorial pediatric brain tumor with recurrent histopathological features suggesting an ependymal differentiation. Because of the recent identification of this neoplastic entity, few histopathological, radiological and clinical data are available. Herein, we present a detailed series of nine cases of PLAGL1-fused supratentorial tumors, reclassified from a series of supratentorial ependymomas, non-ZFTA/non-YAP1 fusion-positive and subependymomas of the young.
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- Visual dysfunction is common in patients with non-functioning pituitary macroadenoma, yet the effectiveness of Optical Coherence Tomography (OCT) in assessing this issue remains unclear.
- A 6-year study involving 20 patients aimed to evaluate the impact of NFPM on neuro-axonal loss by measuring retinal nerve fiber layer (RNFL) thickness over time and analyzing the relationship between OCT changes and optic chiasm compression.
- Findings showed that 40% of patients had RNFL alterations at diagnosis, and 20% experienced thickness reduction during follow-up, but overall visual acuity and field remained stable, indicating OCT may not reliably predict visual dysfunction in these cases.
Background: Contrast-enhanced magnetic resonance imaging (MRI) is the imaging modality routinely used to follow up patients who have undergone surgical resection of brain meningiomas. There are growing concerns about the massive use of gadolinium-based contrast agents (GBCA). Our aim was to evaluate the performance of a new imaging protocol, performed without GBCA injection, in the detection of tumoral residue or local recurrence after surgery of parafalcine and convexity meningiomas.
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- * The majority of the patients had severe COVID-19, with 90% showing abnormal ASL perfusion, particularly hypoperfusion in the temporal poles and frontal lobes, even if traditional MRI scans appeared normal.
- * The findings highlight that over 80% of these patients exhibited significant brain perfusion deficits, suggesting that neurological complications in COVID-19 can occur independently of visible lesions on standard MRI scans.
Article Synopsis
- This study aimed to analyze the brain MRI and FDG-PET/CT findings in 112 COVID-19 patients with neurological issues during recovery, focusing on changes over time and cognitive outcomes.
- Initial MRIs revealed various complications, including brain swelling and strokes, while some conditions showed stabilization or improvement during follow-up; however, 13% developed new issues post-recovery.
- Overall, although most patients improved, a small percentage faced new complications, and there was an observed 3.2% loss in grey matter volume during an average follow-up of five months.