Phase I clinical trial of intracerebroventricular transplantation of allogeneic neural stem cells in people with progressive multiple sclerosis.

We report the analysis of 1 year of data from the first cohort of 15 patients enrolled in an open-label, first-in-human, dose-escalation phase I study (ClinicalTrials.gov: NCT03282760, EudraCT2015-004855-37) to determine the feasibility, safety, and tolerability of the transplantation of allogeneic human neural stem/progenitor cells (hNSCs) for the treatment of secondary progressive multiple sclerosis. Participants were treated with hNSCs delivered via intracerebroventricular injection in combination with an immunosuppressive regimen.

Coexistence of variants in TBK1 and in other ALS-related genes elucidates an oligogenic model of pathogenesis in sporadic ALS.

Variants in tank-binding kinase 1 (TBK1) are responsible for a significant proportion of amyotrophic lateral sclerosis (ALS) cases. In the present study, we analyzed variants in TBK1 extracted by targeted sequencing of 32 genes in a group of 406 Italian patients with ALS. We identified 7 different TBK1 variants in 7 sporadic cases, resulting in a frequency of 1.

The impact of surfactants on Fe(III)-TAML-catalyzed oxidations by peroxides: accelerations, decelerations, and loss of activity.

Iron(III) complexes of tetraamidato macrocyclic ligands (TAMLs), [Fe{4-XC(6)H(3)-1,2-(NCOCMe(2)NCO)(2)CR(2)}(OH(2))](-), 1 (1 a: X = H, R = Me; 1 b: X = COOH, R = Me); 1 c: X = CONH(CH(2))(2)COOH, R = Me; 1 d: CONH(CH(2))(2)NMe(2), R = Me; 1 e: X = CONH(CH(2))(2)NMe(3) (+), R = Me; 1 f: X = H, R = F), have been tested as catalysts for the oxidative decolorization of Orange II and Sudan III dyes by hydrogen peroxide and tert-butyl hydroperoxide in the presence of micelles that are neutral (Triton X-100), positively charged (cetyltrimethylammonium bromide, CTAB), and negatively charged (sodium dodecyl sulfate, SDS). The previously reported mechanism of catalysis involves the formation of an oxidized intermediate from 1 and ROOH (k(I)) followed by dye bleaching (k(II)). The micellar effects on k(I) and k(II) have been separately studied and analyzed by using the Berezin pseudophase model of micellar catalysis.

Arterial hypertension as a risk factor for chronic symmetric polyneuropathy.

Objective: To assess whether arterial hypertension (AH) is an independent risk factor for chronic symmetric polyneuropathy (CSP) in the elderly.

Background: A strong relationship has been detected between AH and distal symmetric polyneuropathy in insulin-dependent and non-insulin-dependent diabetes. However, the correlation between AH and polyneuropathy caused by other clinical conditions has not yet been studied.

The international classification of the epilepsies and epileptic syndromes. An algorithm for its use in clinical practice.

An algorithm has been structured as a guided reading of the international league against epilepsy (ILAE) syndromic classification to be used in clinical practice by less experienced physicians in newly diagnosed patients. The algorithm followed the original structure of the classification, which identifies major syndromic groups, subgroups, and specific syndromes. Validation required two raters, a resident and a board-certified neurologist, to apply the algorithm with different techniques (direct or recorded interview, medical record consultation) to 19 children and 18 adults with epilepsy with information available at the time of diagnosis.