Publications by authors named "F Andreola"
Cellular senescence is not only associated with ageing but also impacts physiological and pathological processes, such as embryonic development and wound healing. Factors secreted by senescent cells affect their microenvironment and can induce spreading of senescence locally. Acute severe liver disease is associated with hepatocyte senescence and frequently progresses to multi-organ failure.
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- * Research is exploring how vitamin deficiencies disrupt communication between the liver and adipose (fat) tissue, potentially contributing to conditions like non-alcoholic fatty liver disease (NAFLD).
- * Recent studies highlight the connection between vitamin deficiency, energy balance regulation, and inflammation, indicating a need for further investigation into these relationships.
Fibroblast growth factor 21 is a hepatokine involved in MASLD progression.
United European Gastroenterol J
October 2024
Article Synopsis
- The study aimed to evaluate the role of FGF21 in metabolic dysfunction-associated steatotic liver disease (MASLD) by analyzing both human samples and animal models.
- Significant increases in FGF21 gene expression and circulating levels were found in MASLD patients as well as in cell and animal models exposed to fatty acids.
- Additionally, the A-allele from the FGF21 rs838133 variant was linked to a higher risk of severe liver conditions in MASLD patients, indicating genetic factors may contribute to disease severity.
To achieve carbon neutrality by 2050, many companies have started implementing sustainability policies. The aim of this work, as result of collaboration between Universities and companies, is to assess the environmental impacts associated with the production of alternative formulations of porcelain stoneware. The proposed formulations contain extraction scraps and chamotte and have promising technological properties.
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