Aging promotes an increase in mitochondrial fragmentation in astrocytes.

Introduction: Brain aging involves a complex interplay of cellular and molecular changes, including metabolic alterations and the accumulation of senescent cells. These changes frequently manifest as dysregulation in glucose metabolism and mitochondrial function, leading to reduced energy production, increased oxidative stress, and mitochondrial dysfunction-key contributors to age-related neurodegenerative diseases.

Methods: We conducted experiments on two models: young (3-4 months) and aged (over 18 months) mice, as well as cultures of senescent and control mouse astrocytes.

Seroprevalence study reveals pertussis underreporting in Brazil and calls for adolescent/young adult boosting: mouse model demonstrates immunity restoration.

Background: Pertussis continues to pose a significant threat despite the availability of effective vaccines. The challenge lies in the vulnerability of infants who have not yet completed their vaccination schedule and in adolescents and adults becoming potential disease carriers.

Methods: We evaluated the seroprevalence of pertussis immunity in a cohort of 1,500 healthy Brazilian volunteers.

Echinococcosis: An Uncommon Cause of Thoracic Pain.

Echinococcosis is caused by larvae, the metacestode stage of the tapeworm , and poses a public health issue in many developing countries. It generally affects a single organ, most commonly the liver or lungs, and rarely involves multiple organs. We present the case of a 24-year-old Indian man living in Portugal, who was admitted to the Emergency Department with left-sided thoracic pain radiating to the back.

Kolmogorov-Arnold Network in the Fault Diagnosis of Oil-Immersed Power Transformers.

Instabilities in energy supply caused by equipment failures, particularly in power transformers, can significantly impact efficiency and lead to shutdowns, which can affect the population. To address this, researchers have developed fault diagnosis strategies for oil-immersed power transformers using dissolved gas analysis (DGA) to enhance reliability and environmental responsibility. However, the fault diagnosis of oil-immersed power transformers has not been exhaustively investigated.