Publications by authors named "F Alhenc-Gelas"
Article Synopsis
- Diabetic nephropathy is closely linked to persistent high blood sugar levels, resulting in both kidney and heart vascular issues, particularly in type 1 diabetes, where genetics play a significant role in risk.
- Extensive research, including genome-wide association studies (GWAS), has identified the angiotensin I-converting enzyme (ACE) gene as a major factor in susceptibility and prognosis for diabetic nephropathy.
- Despite various studies identifying genetic variants like ACE I/D polymorphism and others, no major gene has been conclusively linked, and the effects observed remain relatively modest.
Young-Onset Type 2 Diabetes: When Gluconeogenesis Is Overfueled and Out of Control.
J Clin Endocrinol Metab
September 2024
Sex differences in the control of prolactin secretion are well documented. Sex-related differences in intrapituitary factors regulating lactotroph function have recently attracted attention. Sex differences in prolactinoma development are well documented in clinic, prolactinomas being more frequent in women but more aggressive in men, for poorly understood reasons.
View Article and Find Full Text PDFObjective: The ACE insertion/deletion (I/D) polymorphism has been widely studied in people with diabetes, albeit not with regard to lower-limb amputation (LLA). We examined associations among this polymorphism, plasma ACE concentration, and LLA in people with type 1 diabetes.
Research Design And Methods: ACE I/D genotype and plasma ACE were assessed in three prospective cohorts of participants with type 1 diabetes.