Publications by authors named "F Alconchel"
Background And Aims: Liver transplant (LT) for transplant oncology (TO) indications is being slowly adopted worldwide and has been recommended to be incorporated cautiously due to concerns about mid-long-term survival and its impact on the waiting list.
Approach And Results: We conducted 4 systematic reviews of all series on TO indications (intrahepatic cholangiocarcinoma and perihilar cholangiocarcinoma [phCC]) and liver metastases from neuroendocrine tumors (NETs) and colorectal cancer (CRLM) and compared them using patient-level meta-analyses to data obtained from the United Network for Organ Sharing (UNOS) database considering conventional daily-practice indications. Secondary analyses were done for specific selection criteria (Mayo-like protocols for phCC, SECA-2 for CRLM, and Milan criteria for NET).
Objectives: The objective of this study was to develop and validate 6 checklists for evaluating abdominal pain in clinical simulation scenarios; to assess student competencies in managing 6 clinical cases using OSCE, based on faculty evaluations; and to analyze discrepancies between faculty and student evaluations.
Design: A practical workshop was designed to address 6 clinical scenarios of abdominal surgical conditions. Four scenarios employed medium fidelity simulators, while 2 scenarios employed standardized patient methodology.
Article Synopsis
- - Surgeries for abdominal wall sarcomas often involve extensive resections that create complex defects, but using both porcine dermal xenografts and composite meshes can help with repair while reducing complications.
- - A study involving 19 patients (average age 53.2 years) identified various types of sarcomas and demonstrated that surgical resections and reconstructions using these materials can be effective.
- - After an average follow-up of 38 months, complications occurred in about 31.5% of patients, including wound issues and one death, but overall, the technique showed promising medium-term results.
Thoracoabdominal (TA) normothermic regional perfusion (NRP) should allow the safe recovery of heart and liver grafts simultaneously in the context of controlled donation after circulatory death (cDCD). We present the initial results of cDCD liver transplantation with simultaneous liver and heart procurement in Spain until October 2021. Outcomes were compared with a matched cohort of cDCD with abdominal NRP (A-NRP) from participating institutions.
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- * The study focuses on the role of the NLRP3 inflammasome in liver inflammation and cell death, examining its activation in liver transplant patients to identify potential biomarkers and therapeutic targets.
- * Results show greater inflammasome activation and gene expression in DCD liver samples, correlating with lower survival rates post-transplant, suggesting that monitoring inflammasome activity could be important for improving transplant outcomes.