Publications by authors named "F Al-Obeidi"
Article Synopsis
- Opioids, particularly those targeting the mu opioid receptor (MOR), are effective for severe pain but have serious side effects that limit their use.
- Researchers developed cyclic glycopeptide endomorphin (glycoEM) analogs that provided pain relief similar to morphine while reducing side effects, including lower abuse potential.
- In studies with male and female mice, two glycoEM analogs exhibited higher potency and longer-lasting pain relief at much lower doses than morphine, suggesting potential for future clinical applications.
Terpenes are small hydrocarbon compounds that impart aroma and taste to many plants, including Cannabis sativa . A number of studies have shown that terpenes can produce pain relief in various pain states in both humans and animals. However, these studies were methodologically limited and few established mechanisms of action.
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- * In a study, several terpenes were tested on mice with pain from chemotherapy and inflammation, showing that their pain-relief effects were comparable to standard painkillers like morphine, and they did not produce any rewarding effects typically associated with drugs.
- * Researchers identified the adenosine A receptor in the spinal cord as the main mechanism through which these terpenes provide pain relief, indicating potential for these compounds to be developed into treatments for chronic pain.
Article Synopsis
- Opioids are commonly used to treat both acute and chronic pain, but they come with serious side effects like constipation, dependence, respiratory issues, and overdose risks, contributing to the opioid crisis.
- There is a pressing need for non-addictive pain relief options, and oxytocin has emerged as a potential alternative for both pain management and prevention of opioid use disorder.
- New oxytocin analogues, created by altering its chemical structure for better stability and brain penetration, have demonstrated strong effectiveness in pain relief in mice, indicating promising clinical applications for future research.
The peptide hormone Angiotensin (1-7), Ang (1-7) or (Asp-Arg-Val-Tyr-Ile-His-Pro), is an essential component of the renin-angiotensin system (RAS) peripherally and is an agonist of the Mas receptor centrally. Activation of this receptor in the CNS stimulates various biological activities that make the Ang (1-7)/MAS axis a novel therapeutic approach for the treatment of many diseases. The related O-linked glycopeptide, Asp-Arg-Val-Tyr-Ile-His-Ser-(O-β-D-Glc)-amide (PNA5), is a biousian revision of the native peptide hormone Ang (1-7) and shows enhanced stability in vivo and greater levels of brain penetration.
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