Publications by authors named "F Al-Akayleh"
Article Synopsis
- The study developed a new dexamethasone mixed micellar system (DEX-MM) using Soluplus and Pluronic F-127 to improve drug delivery to the eyes by creating a chitosan-coated version (DEX-CMM).
- The DEX-CMM exhibited high stability, uniform particle size, and effective prolonged drug release compared to a standard DEX suspension, enhancing drug absorption and permeation in ocular tissues.
- Safety tests indicated that DEX-CMM is non-irritating, supporting its potential as an effective method for delivering medication to the eyes.
Imipramine hydrochloride (IMP), a tricyclic antidepressant used for major depression, enuresis, and neuropathic pain, is limited by gastrointestinal complications, low oral bioavailability (44%), and complex dosing requirements. This study aimed to explore a novel non-invasive nasal delivery system using chitosan nanoparticles (Cs NPs) embedded in an in situ gel to address the limitations of oral IMP administration. Cs NPs loaded with IMP were synthesized via ionic gelation and assessed for precision in drug concentration using a validated HPLC method.
View Article and Find Full Text PDFRecent Advances in Ocular Drug Delivery: Insights into Lyotropic Liquid Crystals.
Pharmaceuticals (Basel)
October 2024
This review examines the evolution of lyotropic liquid crystals (LLCs) in ocular drug delivery, focusing on their ability to address the challenges associated with traditional ophthalmic formulations. This study aims to underscore the enhanced bioavailability, prolonged retention, and controlled release properties of LLCs that significantly improve therapeutic outcomes. This review synthesizes data from various studies on both bulk-forming LLCs and liquid crystal nanoparticles (LCNPs).
View Article and Find Full Text PDFArticle Synopsis
- This study focuses on the health concerns related to the leaves of a plant from the Solanaceae family, specifically examining their antioxidant activity and polyphenol content.
- The researchers compared two extraction methods—Methanol-Conventional (MC) and deep eutectic solvents (DES)—and found that the DES method yielded a higher concentration of phenols and flavonoids, as well as more nicotine.
- Despite both extraction methods showing weak antioxidant activity, the DES method demonstrated superior efficiency and environmental benefits for extracting bioactive compounds from the plant.