Publications by authors named "F Ait Kaci"
Cancer and antibiotic-resistant bacterial infections are significant global health challenges. The resistance developed in cancer treatments intensifies therapeutic difficulties. In addressing these challenges, this study synthesised a series of N,N'-dialkyl urea derivatives containing methoxy substituents on phenethylamines.
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- Multiple myeloma (MM) is a type of cancer affecting plasma cells in the bone marrow, characterized by altered metabolism, particularly in glycolysis, lipid metabolism, and mitochondrial respiration.
- Recent advancements in technology, like the Seahorse™ XF analyzer, allow researchers to monitor real-time changes in cell metabolism, specifically glycolytic flux and mitochondrial activity, in various cell types, though non-adherent suspension cells present challenges.
- The authors present an optimized protocol for analyzing live myeloma cells under drug treatment using the XF analyzer, demonstrating that their method yields consistent results, which could be beneficial for future research on metabolic processes in similar cells.
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- Aerobic glycolysis is crucial for cancer cell proliferation, providing energy and building blocks for growth through the M2 isoform of pyruvate kinase (PKM2).
- PKM2 is vital in the glycolytic pathway, transferring phosphate to ADP to produce ATP and pyruvate, with its activity regulated by various mechanisms involving oncogenes and tumor suppressor genes.
- An in vitro kinase assay was developed to study PKM2 phosphorylation by JNK, aiding in understanding kinase-substrate interactions and allowing for the measurement of phosphorylation without radioactive materials.
Hesperidin is a prominent flavanone found in citrus fruits that has a broad range of biological effects, including anti-inflammatory and antioxidant capabilities. The study's objective was to evaluate the effects of hesperidin supplementation on anti-inflammatory and antioxidant parameters such as MDA, TAC, GSH, SOD, and CAT; CRP, TNF-α, IL-6, and IL-4 levels respectively, by analyzing human intervention trials. Google Scholar, PubMed, grey literature databases, and the ClinicalTrials website were scanned to identify eligible studies.
View Article and Find Full Text PDFStachys species belonging to Lamiaceae family have been used for medicinal purposes since ancient times. The aim of the present study was to investigate the chemical compositions and antibacterial, anti-tyrosinase activities of the essential oil of Stachys macrostachya. The essential oil was prepared by hydrodistillation method using a Clevenger-type apparatus and chemical composition was determined by gas chromatography (GC).
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