Publications by authors named "F Affuso"
Article Synopsis
- Despite advancements in treating cardiovascular diseases and cancers, they remain leading causes of hospitalization and death in the Western world.
- Disorders related to hyperinsulinemia and insulin resistance (Hyperin/IR) are underrecognized but linked to multiple health risks, including type 2 diabetes, cardiovascular diseases, and neurodegenerative disorders.
- With over 50% prevalence in the general population and asymptomatic nature, a screening plan for Hyperin/IR is essential to identify at-risk individuals and initiate preventive treatments.
Article Synopsis
- Peripheral insulin resistance (IR) is a key risk factor for various serious health conditions, including type 2 diabetes and neurodegenerative diseases.
- Research has identified the brain as a region that responds to insulin, impacting its metabolism and function, but the exact mechanisms connecting IR and brain health are still not well understood.
- The review will explore the link between insulin resistance and Alzheimer's disease, and propose potential therapeutic strategies to prevent brain IR and its associated impacts.
Unfortunately, cardiovascular diseases and cancers are still the leading causes of death in developed and developing countries despite the considerable progress made in the prevention and treatment of diseases. Maybe we missed something? Insulin resistance (IR) with associated hyperinsulinemia (Hypein) is a silent pandemic whose prevalence is continually growing in developed and developing countries, now exceeding 51% of the general population. IR/Hypein, despite the vast scientific literature supporting its adverse action on the development of type 2 diabetes, cardiovascular alterations, tumors, neurological disorders, and cellular senescence, is not yet considered an independent risk factor and, therefore, is not screened in the general population and adequately treated.
View Article and Find Full Text PDFHeart failure (HF) has become a subject of continuous interest since it was declared a new pandemic in 1997 because of the exponential increase in hospitalizations for HF in the latest years. HF is the final state to which all heart diseases of different etiologies lead if not adequately treated. It is highly prevalent worldwide, with a progressive increase with age, reaching a prevalence of 10% in subjects over the age of 65 years.
View Article and Find Full Text PDFArticle Synopsis
- Cardiovascular mortality remains high despite advancements in prevention and treatment, largely due to underrecognized risk factors.
- Insulin resistance (IR) and hyperinsulinemia (Hyperins) are significant cardiovascular risk factors that have been largely overlooked in both research and clinical practice.
- The article encourages more focus on IR/Hyperins within the scientific community, highlighting its growing prevalence and the need for screening and treatment to mitigate its negative effects on heart health.