Spatiotemporal correlates of emotional conflict processing in typically developing adolescents using magnetoencephalography.

Brain networks involved in emotional conflict processing have been extensively studied using functional magnetic resonance imaging in adults. Yet, the temporal correlates of these brain activations are still largely unknown, particularly in a key phase of emotional development, adolescence. Here, we elucidate the spatiotemporal profile of emotional conflict processing in 24 typically developing adolescents (10-18 years; 22 Caucasian) during an emotional face-word Stroop task.

Advancing ketamine in the treatment hierarchy for refractory depression.

Evidence indicates that ketamine is highly effective, has a lower side effect profile and is better tolerated compared to many augmentation strategies for refractory depression. This, combined with data on psychiatric treatment outcome mediators, suggests that earlier intervention with ketamine could improve outcomes for patients suffering from refractory depression.

Talking to Your Patients About Psychedelics: Using an Informed Approach and Understanding Indications, Risks, and Benefits.

The Psychiatric Consultation Service at Massachusetts General Hospital sees medical and surgical inpatients with comorbid psychiatric symptoms and conditions. During their twice-weekly rounds, Dr Stern and other members of the Consultation Service discuss diagnosis and management of hospitalized patients with complex medical or surgical problems who also demonstrate psychiatric symptoms or conditions. These discussions have given rise to rounds reports that will prove useful for clinicians practicing at the interface of medicine and psychiatry.

A pathogen effector co-opts a host RabGAP protein to remodel pathogen interface and subvert defense-related secretion.

Pathogens have evolved sophisticated mechanisms to manipulate host cell membrane dynamics, a crucial adaptation to survive in hostile environments shaped by innate immune responses. Plant-derived membrane interfaces, engulfing invasive hyphal projections of fungal and oomycete pathogens, are prominent junctures dictating infection outcomes. Understanding how pathogens transform these host-pathogen interfaces to their advantage remains a key biological question.

Identification of Potent, Broad-Spectrum Coronavirus Main Protease Inhibitors for Pandemic Preparedness.

The COVID-19 pandemic highlights the ongoing risk of zoonotic transmission of coronaviruses to global health. To prepare for future pandemics, it is essential to develop effective antivirals targeting a broad range of coronaviruses. Targeting the essential and clinically validated coronavirus main protease (M), we constructed a structurally diverse M panel by clustering all known coronavirus sequences by M active site sequence similarity.