[Methodological aspects of evaluation of potential lipid capacity for peroxidation from the serum levels of TBA-active products during iron ion stimulation].

The authors propose a simple and reproducible procedure for using iron ions to stimulate serum lipid peroxidation, with TBA-active products being further determined. The procedure determines the reserve of lipids that can be oxidized during oxidative stress. A combination of direct studies and correlation analysis suggests that low-density lipoproteins and very low-density lipoproteins are the major substrates for lipid peroxidation while high-density lipoproteins show a high resistance to this process.

[Glomerular filtration rate is an indicator of endothelial function at early stages of chronic kidney disease].

Aim: To study effects of glomerular filtration rate (GFR) reduction on endothelial function in patients at early stages of chronic renal kidney (CKD).

Material And Methods: Endothelial function of 101 patients with CKD of stage I-III was examined using reactive hyperemia test, dopplerography of skin vessels with ionophoresis of acetylcholin and nitroglycerin, lipidogram parameters, homocistein and annexin A5 levels, intima-media complex thickness of the common carotid artery, echocardiography findings.

Results: Cardiovascular complications risk factors were found in all the patients: increased body mass index, arterial hypertension, dyslipoproteinemia, hyperhomocysteinemia.

[Lipid peroxidation and the system of antioxidant protection in patients with chronic glomerulonephritis and normal kidney azoturic function].

As indicated by blood tests, chronic glomerulonephritis (CGN) patients with intact renal function have impaired lipid peroxidation and antioxidant defense. In nephrotic syndrome these plasm changes are more pronounced, but red cells remain relatively intact. Persistent nephrotic syndrome produces a trend to shifts in red blood picture.

[The blood pro- and antioxidant status in patients with chronic glomerulonephritis and disordered kidney function undergoing treatment with peroral sorbents].

It was found that there is unbalance between accumulation of lipid peroxidation (LPO) products and antioxidant potential in blood plasma and red cells from chronic glomerulonephritis patients with renal dysfunction. The unbalance cannot be corrected by standard conservative therapy. Oral sorbents result in normalization of the plasma abnormalities, but a long-term intake of coal depletes antioxidant defense which is likely to occur because of low plasma tocopherol levels.

[Features of lipid peroxidation in the blood of patients with chronic glomerulonephritis at the stage of renal dysfunction in the presence of nephrotic syndrome].

An increase in the rate of lipid peroxidation and exhaustion of protective antioxidative factors were detected in blood of patients with chronic glomerulonephritis in renal failure. The severity of renal failure did not affect noticeably the alteration of the patterns studied, while the most serious impairments were found in patients with the nephrotic syndrome. The value of antioxidation coefficient whose calculation is given in the paper may be used as an integral pattern evaluating impartially the ratio between pro- and antioxidation factors.