Publications by authors named "F A Sgura"
Transcatheter Approaches to Atrial Functional Mitral Regurgitation: How Far Have We Come?
Catheter Cardiovasc Interv
December 2024
Functional mitral regurgitation (MR) is associated with increased cardiovascular morbidity and mortality and over the past decade, the diagnosis of atrial functional mitral regurgitation (aFMR) has been increasingly observed in the elderly, especially in those with atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF). Annular enlargement, perturbations of annular contraction, and atriogenic leaflet tethering distinguish the pathophysiology of aFMR from the one of ventricular origin. However, no consensus provides recommendations regarding the differential diagnosis and the subsequent management of aFMR.
View Article and Find Full Text PDFNatural History of Coronary Atherosclerosis in Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement: The Role of Quantitative Flow Ratio.
Circ Cardiovasc Interv
August 2024
Background: The prognostic impact of functionally significant coronary artery disease, as assessed with quantitative flow ratio (QFR), in patients with severe aortic stenosis treated with transcatheter aortic valve replacement is unknown.
Methods: This is a retrospective study with blind analysis of angiographic data, enrolling consecutive patients with severe aortic stenosis treated with transcatheter aortic valve replacement at 4 Italian centers. None of the patients enrolled received pre-transcatheter aortic valve replacement or concomitant coronary revascularization, either for the absence of significant coronary stenoses or by clinical decision.
Article Synopsis
- Patients with atrial fibrillation (AF) undergoing transcatheter aortic valve implantation (TAVI) experience worse short-term outcomes, including higher rates of acute kidney injury and major bleeding compared to those in normal sinus rhythm.
- The study analyzed TAVI patients from 2012 to 2022, focusing on short-term hospital outcomes and long-term effects at an average follow-up of 3.2 years.
- Results showed that both preexisting and new-onset AF increased the risk of all-cause death and hospitalization after TAVI, indicating a significant link between AF and negative health outcomes in this patient group.
Article Synopsis
- - This study examined the long-term results for patients with severe aortic valve disease who underwent replacement surgery using advanced stentless aortic prostheses, specifically Medtronic's 3F® and LivaNova's Pericarbon Freedom™ models.
- - From June 2003 to September 2015, 548 patients were followed, with an overall early mortality rate of 2.55% and an observed median follow-up time of 6.77 years, revealing that 91% survived cardiac-related issues at the 12-year mark.
- - Key findings included 86% of patients avoiding structural valve deterioration, 95% remaining free from endocarditis, and a similar percentage not needing reoperation related to the valve
Cor pulmonale is a clinical syndrome associated with pulmonary hypertension, frequently complicated by congestive heart failure, commonly caused by chronic obstructive pulmonary disease (COPD). Most patients with cor pulmonale have tachycardia. However, heart rate (HR) reduction represents a primary treatment goal to improve the survival and quality of life in these patients.
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