[Insulin shock treatment in The Hague from 1937 to the end of the 1950s].

Background: Insulin shock treatment began to be applied in the 1930s to patients with a clinical diagnosis of schizophrenia. Although lacking theoretical and empirical support, the therapy was received enthusiastically and applied quite frequently. However, it quietly disappeared from the treatment repertories in the 1950s.

Two new closely related rat models with relevance to arterial thrombosis--efficacies of different antithrombotic drugs.

Two thrombosis models in rats are described in which mixed type thrombi are formed at arterial and venous flow rates. The models, containing a silk thread in the aorta and vena cava, respectively, were characterised for the activity of three platelet inhibitors, three thrombin active site inhibitors and five glycosaminoglycans (GAGs). In the two models a similar highly platelet-dependent thrombus developed both in size and composition during the first 10 min after insertion of the silk thread.