Publications by authors named "F A Lara"
In this manuscript, an oxidative carbon-carbon bond forming reaction to construct the framework of alkaloids such as scholarinine A is explored using a constrained substrate. Instead of the desired carbon-carbon bond formation between an indole C3 position and a malonate group, a competing carbon-nitrogen bond between the malonate and indole C3 position was observed to form. This work adds to the growing body of substrates for oxidative carbon-carbon bond formation and importantly, demonstrates that these reactions are challenging for some conformationally constrained substrates.
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- A significant portion of the genome of studied strains has become pseudogenes, but their genetic similarity remains high, with over 99% identity among isolates globally.
- The research focused on comparing three strains of a pathogen, including a reference strain and two from Brazilian leprosy relapse patients, highlighting differences in genotype and interaction with human cells.
- Despite minimal genetic differences, the strains displayed notable phenotypic changes, impacting their growth and interaction with host cells, which could enhance understanding of leprosy's varied clinical outcomes.
Preliminary Functional Analysis of the Gut Microbiome in Colic Horses.
Animals (Basel)
November 2024
The gut microbiome plays a critical role in maintaining horse health, influencing digestion, immunity, and overall well-being. However, in certain conditions like colic, there is evidence of significant alterations in the microbial community. To analyze the composition of the fecal microbiome and the enriched predicted metabolic functions of horses with colic compared to a control group, 14 horses with colic and 14 control horses were recruited.
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- Intercontinental disjunctions in biogeography are intriguing patterns often seen in bryophytes, which can disperse over long distances, creating unexpected species distributions.
- This study focuses on a moss with a distribution between East Africa and southern India, examining whether it represents a single species or comprises closely-related but overlooked species.
- Utilizing both morphological and molecular methods, the research identifies two distinct species, reveals their overlapping ranges in East Africa, and emphasizes the importance of recognizing overlooked species in understanding bryophyte biogeography.
Article Synopsis
- - The Zika virus can cause Congenital ZIKV syndrome (CZS) during pregnancy, leading to malformations like microcephaly, with varying prevalence across Brazil, particularly in the Northeast and Central-West regions.
- - A study found that exposure to the agrochemical 2,4-dichlorophenoxyacetic acid (2,4D), commonly used in Brazil, worsens the neurotoxic effects of ZIKV in human cells and mice models, resulting in smaller brain size and increased cell death.
- - There is a notable correlation between the prevalence of CZS and the use of 2,4D in certain Brazilian regions, suggesting that this agrochemical may enhance the transmission of Z