[Oxidative and free-radical processes in the mechanism of toxic effect of anti-diabetic drugs dicarboxylic acids derivatives].

Dynamics of changes in the processes of the lipids free-radical peroxide oxidation (LPO), state of the monooxygenase system (MOS) and system of anti-oxidant protection (SAOP) in the liver and blood of rats under multiple peroral and inhalatory expositions of anti-diabetic drugs--dicarboxylic acids derivatives: phensuccinalum (PhS) and diacamph (Dc) in toxic and sub-toxic doses is studied. It has been found that one of the key biochemical mechanisms which determines the early signs of the toxic damage in the cells and organism under the effect of certain doses/concentrations of PhS (500 and 100 mg/kg, 20.2 mg/m3) and Dc (1000 mg/kg) consists in intensification of the free-radical processes, including, in particular, LPO combined with activation of MOGS and inhibition of SAOP in microsomal fraction of the liver.

Chronobiological aspects of melatonin-produced antioxidant effects in senescent rats.

Melatonin in low doses of (0.05 and 0.5 mg/kg) administered to senescent rats in winter and summer inhibited free radical oxidation and LPO.

[Lipid peroxidation and antioxidant defence in patients with pneumoconiosis and dust-induced bronchitis].

Lipids peroxidation (LP) and antioxidant defence (AD) were compared in the patients facing pneumoconiosis and dust bronchitis. The studied group included 35 patients with suspected pneumoconiosis, 75 patients facing the 1 grade of pneumoconiosis, 43 coniotuberculosis patients and 43 patients with dust bronchitis. Active LP was demonstrated, values and intensities of its stages depended on the origin and severity of disease.