[Problems of diagnosis and prevention of occupational malignancies].

The authors presented statistics on quantity of registered occupational malignancies in Russian Federation and some foreign countries, analyzed causes of difficult diagnosis of occupational malignancies, suggested ways to improve the situation.

[Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients from Yakutia].

DNA polymorphism is an important component of the interindividual variation in reactions of patients to the same drugs. In this work, evaluation of the association between polymorphisms in 106 genes involved in key processes of cellular activity (xenobiotic metabolism, DNA repair, the cell cycle, and apoptosis), and outcomes in a cohort of Yakut ovarian cancer patients receiving cisplatin-based chemotherapy was carried out. The polymorphism in the CDKN1B gene (rs34330) was found to be associated with complete tumor response and progression-free survival.

[CYP2E1 gene polymorphism and ovarian cancer risk in the Yakut population].

The CYP2E1 gene polymorphism has been studied in Yakut women with ovarian cancer and without cancer. The two groups have been found to substantially differ in the frequency of the CYP2E1* 1D allele (with a 96-bp insertion in the promoter region of the gene): it is more frequent in healthy women (16.3 versus 7.

Pharmacogenomics of cisplatin-based chemotherapy in ovarian cancer patients of different ethnic origins.

Aim: There is a substantial difference between Asians and Caucasians in their reaction to platinum drugs. To determine whether population-related genomics contribute to differences in patient outcomes, pharmacogenomic relevance of polymorphisms in some genes, the protein activities of which may affect aspects of cisplatin metabolism, were evaluated.

Patients & Methods: Nineteen polymorphisms in ten genes were tested for correlations with the efficacy and toxicity of a cisplatin-cyclophosphamide regimen in Yakut and Russian patients with ovarian cancer.

[Physician continuing education on occupational diseases as an integral part of the national project "Health Promotion"].

The author's concepts are evaluated positively and additional organizational and practical recommendations are suggested to increase quality of doctors' postgraduate training in occupational therapy.