Publications by authors named "F A Iskander"

Article Synopsis
  • - Spontaneous coronary artery dissection (SCAD) is a rare but significant cause of chest pain and heart problems, especially in younger individuals and women, and it often mimics acute coronary syndrome (ACS).
  • - Unlike typical ACS patients, those with SCAD frequently lack common risk factors associated with heart disease, making diagnosis challenging and crucial for appropriate treatment.
  • - A case study is presented involving a 61-year-old woman with no prior heart issues who experienced chest pain and was ultimately diagnosed with SCAD after undergoing coronary angiography.
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We report a case of a 44-year-old man with a clinical history of Tetralogy of Fallot status post staged surgical correction with mechanical pulmonic valve replacement who presented with progressive exertional dyspnea in the setting of non-compliance with anticoagulation. In the context of this suggestive clinical presentation, the diagnosis of mechanical pulmonic valve thrombosis (MPVT) was made possible via multimodality imaging, including transthoracic echocardiogram and cardiac computed tomography angiography. Due to the uncommon nature of the condition, the patient was treated with systemic thrombolysis and anticoagulation using evidence-based guidelines, largely extrapolated from left-sided mechanical valve thrombosis.

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Background: Data on the diagnostic and prognostic value of subtle abnormalities on myocardial perfusion imaging (MPI) are limited.

Methods And Results: In a retrospective single-center cohort of patients who underwent regadenoson SPECT-MPI, near-normal MPI was defined as normal left ventricular ejection fraction (LVEF ≥ 50%) and a summed stress score (SSS) of 1-3 vs SSS = 0 in normal MPI. Borderline ischemia was defined as normal LVEF, SSS = 1-3, and a summed difference score (SDS) of 1 vs SDS = 0 in the absence of ischemia.

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Background: There are limited data on the prognostic utility of regadenoson SPECT myocardial perfusion imaging (MPI) in patients with end-stage renal disease (ESRD).

Methods And Results: In a single-center, retrospective study, we analyzed consecutive ESRD patients who underwent regadenoson SPECT-MPI. The severity of MPI abnormalities and ischemic burden were determined quantitatively.

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