Publications by authors named "F A Isa"
Article Synopsis
- The study investigates how antiviral monoclonal antibodies (mAbs), particularly casirivimab and imdevimab (CAS+IMD), affect immune responses when individuals are vaccinated against SARS-CoV-2 after receiving mAb treatment.
- It was found that the presence of CAS+IMD during vaccination reduced the effectiveness of the vaccine in generating neutralizing antibodies, though other immune responses remained intact.
- This reduction in antibody production is linked to "epitope masking," but can be reversed with booster shots, and influences the immune response differently in those who had not yet begun their natural immunity when treated with mAbs.
Article Synopsis
- The study examines the link between anxiety, depression, and gastrointestinal (GI) symptoms in university students through a campus-wide survey.
- A total of 437 students from three public medical universities in Saudi Arabia participated, using standardized measures for mental health and a tailored questionnaire for GI symptoms.
- Results showed a significant correlation between high levels of anxiety and depression with GI issues, indicating the need for integrated health interventions to support both mental and physical well-being among students.
Effect of timing of casirivimab and imdevimab administration relative to mRNA-1273 COVID-19 vaccination on vaccine-induced SARS-CoV-2 neutralising antibody responses: a prospective, open-label, phase 2, randomised controlled trial.
Lancet Infect Dis
January 2025
Background: Deeper insight is needed on how monoclonal antibodies (mAbs) affect vaccine-mediated immune responses when targeting the same protein. We describe the first prospective randomised trial designed to understand mAb-mediated alterations in vaccine-induced immune responses to SARS-CoV-2 spike protein epitopes.
Methods: This randomised, open-label, parallel-group study assessed the potential interaction of a mAb combination, casirivimab and imdevimab, with a vaccine, Moderna's mRNA-1273, in healthy SARS-CoV-2 immunologically naive, seronegative adults at six centres in the USA.
The mission of the JT-60SA project is to complement ITER's capabilities by addressing the fundamental physics and engineering challenges necessary to develop a practical and reliable fusion power plant. Diagnostics play a pivotal role in achieving this mission, especially the Thomson Scattering (TS) diagnostic systems developed by a collaborative Japan-EU team. The edge Thomson scattering of JT-60SA is tailored to measure the low field side outer region of the plasma, in particular, to resolve the electron temperature Te and density ne.
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- Myocardial infarction (MI), or heart attack, occurs when blood supply to the heart muscle is reduced, often leading to serious health complications like cell death and potentially rapid death.
- The primary cause of MI is coronary artery disease, which is also the leading cause of death in the U.S., with symptoms like chest pain and changes on an electrocardiogram.
- A study examining MI incidence in Saudi Arabia from 2000 to 2024 highlighted that lifestyle choices and medical conditions significantly influence heart attack risk, emphasizing the need for healthier habits to reduce incidence.