Publications by authors named "F A Frost"
Non-tuberculous Mycobacterial Pulmonary Disease (NTM-PD) is a chronic disease characterised by progressive inflammatory lung damage due to infection by non-tuberculous mycobacteria (NTM). Global prevalence of NTM-PD is generally low but is rising, likely due to a combination of increased surveillance, increasing multimorbidity and improved diagnostic techniques. Most disease is caused by Mycobacterium avium complex species.
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- SGLT2 inhibitors and GLP-1 receptor agonists are diabetes treatments that may also lower the risk of pneumonia and severe sepsis in type 2 diabetes patients.
- A study using electronic medical records analyzed the effects of these drugs versus traditional glucose-lowering therapies and found significant reductions in pneumonia and sepsis risk.
- The findings suggest that both treatments could improve overall health outcomes beyond glucose control, but more research is needed to understand their full impact.
Background: Macrolide maintenance therapy (MMT) has demonstrated notable efficacy in reducing exacerbation in patients with bronchiectasis, which is a major risk factor for cardiovascular events. However, a comprehensive assessment of the cardiovascular benefits and safety profile of MMT in this population is lacking.
Methods: This territory-wide cohort study analyzed patients diagnosed with bronchiectasis in Hong Kong between 2001 and 2018.
Article Synopsis
- Diet plays a significant role in metabolic syndrome (MetS), with a focus on both dietary diversity and quality being essential for obesity prevention and metabolic health.
- Data from a study involving 6,753 individuals revealed that higher dietary diversity (DDS) is linked to a lower risk of MetS, while dietary quality (DQS) showed limited positive associations.
- The findings suggest that while dietary diversity enhances gut microbiota diversity and leads to a healthier metabolic state, dietary quality may not be as influential, indicating that future dietary guidelines should prioritize a variety of foods over simply focusing on nutritional content.
Article Synopsis
- * A patient with compound heterozygous DDX41 variants exhibited symptoms including bone dysplasia and ichthyosis, and analysis of their skin cells showed reduced DDX41 levels and disruption of immune gene activation.
- * Further studies revealed significant gene dysregulation and increased periostin mRNA in the patient’s cells, indicating that impaired DDX41 function and altered periostin expression likely contribute to the patient's complex disorder.