Publications by authors named "F A Frick"

Article Synopsis
  • GNU Health is an open-source clinical information system designed to manage health records, hospital information, and laboratory data effectively and affordably.
  • Despite its advantages, GNU Health is not widely used in Europe due to barriers like regulatory challenges, interoperability issues, and resistance from existing proprietary systems.
  • The paper highlights potential benefits of adopting GNU Health, alongside a case study and expert interviews that discuss why overcoming these obstacles is difficult.
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Article Synopsis
  • Pulmonary arterial hypertension (PAH) is a rare but serious condition with a median survival of about 7 years, and current treatments mainly relieve symptoms without addressing the disease itself.
  • CS1 is a new oral treatment based on valproic acid, which may offer multiple therapeutic benefits, including reducing lung pressure and reversing vascular issues associated with PAH.
  • A Phase 1 study showed CS1 is safe and well-tolerated, and a current Phase 2 trial is assessing its effects on various health outcomes to inform future studies and potential wider use.
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Ponds occupy a large share of standing water worldwide and play an important role in providing various ecosystem services. There are concerted efforts of the European Union either to create new ponds, or to restore and preserve existing ponds as nature-based solutions to provide benefits to ecosystem and human well-being. As part of the EU PONDERFUL project, selected pondscapes (i.

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Transgenic Late-onset OBesity (LOB) rats slowly develop a male-specific, autosomal dominant, obesity phenotype with a specific increase in peri-renal white adipose tissue (WAT) depot and preserved insulin sensitivity (Bains et al. in Endocrinology 145:2666-2679, 2004). To better understand the remarkable phenotype of these rats, the lipid metabolism was investigated in male LOB and non-transgenic (NT) littermates.

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It is known that bovine GH (bGH) transgenic mice have increased body mass, insulin resistance, and altered lipoprotein metabolism when fed a normal diet (ND). In this study, the effects of 8 wk of high-fat diet (HFD) were investigated in 6-month-old male bGH mice. Although littermate controls had unchanged energy intake, energy intake was higher in the bGH mice on a HFD than on a low-fat diet.

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