Publications by authors named "F A Cioffi"
This study presents the development of an analytical characterization strategy tailored to end products derived from an alfalfa ()-based biorefinery with particular emphasis on protein concentrates and phenolic-enriched fractions. Our approach began with a comprehensive full-factorial experimental design aimed at optimizing the extraction process, taking care to design a biocompatible extraction protocol. Liquid chromatography with tandem mass spectrometry (LC-MS/MS) techniques were used to characterize the molecular profile of the extracts.
View Article and Find Full Text PDFIntroduction: The contribution of Cannabinoid type 1 receptor (CB1) in mitochondrial energy transduction mechanisms and mitochondrial activities awaits deeper investigations. Our study aims to assess the impact of CB1 absence on the mitochondrial compartment in the liver, focusing on both functional aspects and remodeling processes.
Methods: We used CB1 and CB1 male mice.
Article Synopsis
- - The study explored how the transcription factors Nkx2-1 and Pax8 influence thyroid development and brain functions by examining mice with genetic mutations affecting these factors, focusing on brain abnormalities linked to thyroid conditions.
- - DHTP mice, which have both systemic and brain hypothyroidism, displayed altered neurotransmitter systems, reduced expression of synaptic and glutamate receptor proteins, and imbalances in mitochondrial dynamics compared to control mice.
- - The findings suggest that Nkx2-1 and Pax8 mutations lead to neuroanatomical and neurochemical changes in the brain, highlighting potential targets for managing brain dysfunctions related to thyroid imbalances.
Comparative effects of 3,5-diiodo-L-thyronine and 3,5,3'-triiodo-L-thyronine on mitochondrial damage and cGAS/STING-driven inflammation in liver of hypothyroid rats.
Front Endocrinol (Lausanne)
September 2024
Maintaining a well-functioning mitochondrial network through the mitochondria quality control (MQC) mechanisms, including biogenesis, dynamics and mitophagy, is crucial for overall health. Mitochondrial dysfunction caused by oxidative stress and further exacerbated by impaired quality control can trigger inflammation through the release of the damage-associated molecular patterns (mtDAMPs). mtDAMPs act by stimulating the cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) pathway.
View Article and Find Full Text PDFBackground: The main contribution of this article is establishing a set of behaviors and successful actions experimenting the Ipacs' (Institutional & Public Coaching Services) methodology on implementation of the National Recovery Plan (NRP), approved in Italy in 2021 to overcome the socio-economic impact of the pandemic. This research is aimed at pointing out emotional intelligence (EI) behaviors related to the activities of the NRP with respect to the National Health System (NHS).
Participants And Procedure: Fifty-six professionals were provided with an integrated pathway with coaching, participative art and mentoring from January to June 2022.