Publications by authors named "F A Brouwer"
The objective of this study was to investigate the relationship between sublingual microcirculatory parameters and the severity of the disease in critically ill coronavirus disease 2019 (COVID-19) patients in the initial period of Intensive Care Unit (ICU) admission in a phase of the COVID-19 pandemic where patients were being treated with anti-inflammatory medication. In total, 35 critically ill COVID-19 patients were included. Twenty-one critically ill COVID-19 patients with a Sequential Organ Failure Assessment (SOFA) score below or equal to 7 were compared to 14 critically ill COVID-19 patients with a SOFA score exceeding 7.
View Article and Find Full Text PDFArticle Synopsis
- High concentrations of oxygen increase the risk of hyperoxemia in infants with persistent pulmonary hypertension (PPHN), leading to the study of its occurrence during treatment with inhaled nitric oxide (iNO).
- A review of medical records from 181 infants revealed that a significant percentage experienced hyperoxemia, with 82% having at least one arterial oxygen tension (PaO) greater than 13 kPa.
- The findings indicate that while treating PPHN aims to manage hypoxemia, hyperoxemia is a common, inadvertent side effect during iNO therapy.
Article Synopsis
- The study aimed to compare the effects of two target ranges for peripheral oxygen saturation (SpO) on hypoxic and hyperoxic episodes in infants receiving respiratory support.
- Conducted in a neonatal unit in the Netherlands, the randomized cross-over study involved 27 infants, assessing their oxygen levels while using the OxyGenie controller.
- Results indicated that while a higher SpO target range (92%-96%) reduced the frequency of hypoxic episodes, it also increased the frequency of hyperoxic episodes, suggesting the potential of automated oxygen titration in neonatal care.
Ferroptosis is an iron- and reactive oxygen species (ROS)-dependent form of regulated cell death, that has been implicated in Alzheimer's disease and Parkinson's disease. Inhibition of cystine/glutamate antiporter could lead to mitochondrial fragmentation, mitochondrial calcium ([Ca]) overload, increased mitochondrial ROS production, disruption of the mitochondrial membrane potential (ΔΨ), and ferroptotic cell death. The observation that mitochondrial dysfunction is a characteristic of ferroptosis makes preservation of mitochondrial function a potential therapeutic option for diseases associated with ferroptotic cell death.
View Article and Find Full Text PDFDysfunction of the immune system and mitochondrial metabolism has been associated with Parkinson's disease (PD) pathology. Mutations and increased kinase activity of leucine-rich repeat kinase 2 (LRRK2) are linked to both idiopathic and familial PD. However, the function of LRRK2 in the immune cells under inflammatory conditions is contradictory.
View Article and Find Full Text PDF