NaHS alters synaptic plasticity proteins and enhances dendritic arborization to improve cognitive and motor deficits after traumatic brain injury in mice.

Background And Purpose: Traumatic brain injury (TBI) is a complex medical condition affecting people globally. Hydrogen sulfide (HS) is a recently discovered gaseous mediator and is dysregulated in the brain after TBI. Sodium hydrogen sulfide (NaHS), a known donor of HS, is beneficial in various biological processes involving aging and diseases, including injury.

Development and Validation of Rapid and Cost-Effective RP-HPLC/UV Method for Determination of Cetirizine/Levocetirizine in Blood Plasma of Smokers and Non Smokers: a Two Cohort Comparative Study.

In this research study, a simple, rapid, sensitive, and cost-effective Reverse Phase High Performance Liquid Chromatography method was developed and validated for determination of Cetirizine and Levocetirizine in human plasma. The drugs were separated on an ACE Generix100-5 C18 RP (250 × 4.6 mm, 5 μm) column, using Acetonitrile and Distilled water pH 7 (59:41 v/v) as mobile phase with a flow rate of 1.

Self-assembled latanoprost loaded soluplus nanomicelles as an ophthalmic drug delivery system for the management of glaucoma.

Glaucoma, a leading cause of blindness due to elevated intraocular pressure (IOP), is managed with medications like latanoprost (LAT), a prostaglandin analogue, to enhance aqueous outflow. Despite the challenge posed by eye anatomy and tear dynamics, effective ocular bioavailability via topical administration remains elusive. This study aims to optimize self-assembled nanomicelles incorporating LAT, an anti-glaucoma drug, belonging to BCS Class II (low solubility and high permeability) via a two-level, two-factor full factorial design, the nanomicelles were formulated via direct dissolution method and validated using design of expert.

Effective Management of Type-2 Diabetes Mellitus with Unani Medications: A Case Report.

Introduction: Diabetes mellitus (DM) presents a formidable global health challenge, with conventional treatments often accompanied by limitations and adverse effects. Moreover, accessibility and affordability of conventional treatments remain barriers for many individuals, particularly in low-resource settings. Hence, there is a compelling need to explore alternative therapeutic modalities, such as Unani medicine, which offer the potential for effective management of type 2 diabetes mellitus (T2DM) while potentially mitigating these drawbacks.

Neuroprotective effect of vitamin B supplementation on cognitive functions and neuronal morphology at different time intervals after traumatic brain injury in male Swiss albino mice.

Traumatic brain injury is a highly irreversible process that consists of primary as well as secondary injury which develops and progresses over months to years, leading to cognitive dysfunctions. Vitamin B received considerable interest due to its potential therapeutic properties. The pathways of vitamin B are closely related to neuronal survival but its effects on the pathophysiology of injury with respect to cognition is a relatively unexplored area of research.