Publications by authors named "F A Abu-Bedair"
Article Synopsis
- The study investigates the impact of serum lipid levels and tissue DNA content on breast cancer among Egyptian women, focusing on premenopausal and postmenopausal patients.
- Results indicate that premenopausal women have significantly increased total lipids and cholesterol, while postmenopausal women show higher triglycerides, with DNA content varying by menopause status and tumor grade.
- The findings suggest that elevated serum lipid levels may indicate a higher risk for breast cancer, and DNA content could help tailor therapy based on the cancer's malignancy level.
Aims And Background: Hormones are considered to be an important factor in the etiology of breast cancer. Serum hormonal profiles of premenopausal and postmenopausal breast cancer patients as well as estrogen receptor (ER) concentrations in breast cancer tissues were examined in an attempt to establish a possible association between hormones and breast cancer risk and to elucidate the biological features of the disease among Egyptian female patients.
Methods: Levels of estradiol (E2), testosterone (T), progesterone (P), LH, FSH, prolactin, T3, T4 and TSH were measured by highly specific radioimmunoassays in the sera of women with breast cancer and compared to those of control subjects.
In menstruating 20-29 year old breast cancer patients, the total estrogen level showed a significant increase in the early follicular phase compared to normal healthy subjects. Such a difference was not observed in 30-45 year-old patients. A nonsignificant decrease was observed in the estradiol level of premenopausal breast cancer patients compared to normal healthy subjects.
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