Long-term use of colchicine is associated with incident cirrhosis: a real-world cohort study.

Introduction: Chronic effect of colchicine on the liver was not studied enough. We aimed to examine the association between long term colchicine use and incident cirrhosis among new colchicine initiators.

Study: Using database of Maccabi Healthcare Services (MHS), we included all patients aged ≥18 years old who initiated colchicine between 1 January 2000 and 31 December 2018 and followed them until the earliest of the following: incident cirrhosis, leaving MHS, death or 31 December 2020.

Epstein-Barr Virus Sequence Variations Among the Understudied Nasopharyngeal Carcinoma Patients of Diverse Ancestries in Southeast Asia.

Epstein-Barr virus (EBV) is associated with cancers, including lymphomas and nasopharyngeal carcinoma (NPC). To date, risk variants for NPC were mainly identified from Chinese populations, which dominated the world's total number of cases. Although Southeast Asia (SEA) countries have among the world's top yet intriguingly diverse NPC age-standardized incidence rates across subpopulations, data on EBV from SEA remains scarce.

Prevalence and impact of sarcopenia in patients with inflammatory bowel diseases: A prospective cohort study.

Background: Inflammatory bowel disease (IBD) patients with sarcopenia are at increased morbidity risk. The aim of this study was to assess the prevalence of sarcopenia in IBD outpatients using both morphological and functional criteria.

Methods: In this prospective cohort study, all IBD patients admitted to the day hospital unit between March 01 and 31, 2023 were included.

New nanomanufacturing strategy through bioinspired design, for promising treatment of Parkinson's disease.

This study attempts to develop a new nanomanufacturing strategy for Parkinson's disease using natural biodegradable components (chitosan, albumin, and dopamine) that can penetrate the blood-brain barrier (BBB) due to biocompatibility, biodegradability, targeted delivery, and controlled drug release. It was prepared, thoroughly optimized and characterized using various biophysical and chemical techniques. Results showed that the nanomanufactured system (molar ratio of 1:0.

EPIDEMIOLOGY OF FEBRILE SEIZURES DURING THE COVID-19 PANDEMIC: A CANADIAN IMMUNIZATION MONITORING PROGRAM-ACTIVE (IMPACT) STUDY.

Active surveillance for febrile seizures was conducted at 12 Canadian pediatric centers (August 2021-December 2022). Of 3367 cases, 649 (19%) were hospitalized, 156/3367 (5%) had laboratory-confirmed acute SARS-CoV-2 infection, 363 (11%) had non-SARS-CoV-2 infection and 107 (3%) occurred as adverse events following immunization (vaccinated within 15 days before presentation). Febrile seizures were more frequently associated with infection than vaccination.